EC 2.7.1.200 - Protein-Nπ-phosphohistidine—galactitol phosphotransferase

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IntEnz Enzyme Nomenclature
EC 2.7.1.200

Names

Accepted name:
protein-Nπ-phosphohistidine—galactitol phosphotransferase
Other names:
gatABC (gene names)
galactitol PTS permease
EIIGat
Enzyme IIGat
Systematic name:
protein-Nπ-phospho-L-histidine:galactitol Nπ-phosphotransferase

Reaction

Comments:

This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate—protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00795
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Lengeler, J.
    Nature and properties of hexitol transport systems in Escherichia coli.
    J. Bacteriol. 124 : 39-47 (1975). [PMID: 1100608]
  2. Nobelmann, B., Lengeler, J. W.
    Sequence of the gat operon for galactitol utilization from a wild-type strain EC3132 of Escherichia coli.
    Biochim. Biophys. Acta 1262 : 69-72 (1995). [PMID: 7772602]
  3. Nobelmann, B., Lengeler, J. W.
    Molecular analysis of the gat genes from Escherichia coli and of their roles in galactitol transport and metabolism.
    J. Bacteriol. 178 : 6790-6795 (1996). [PMID: 8955298]

[EC 2.7.1.200 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.200]