EC 2.7.1.185 - Mevalonate 3-kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.185

Names

Accepted name:
mevalonate 3-kinase
Other name:
ATP:(R)-MVA 3-phosphotransferase
Systematic name:
ATP:(R)-mevalonate 3-phosphotransferase

Reaction

Comments:

Mevalonate 3-kinase and mevalonate-3-phosphate-5-kinase (EC 2.7.1.186) act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum. Mevalonate 3-kinase is different from mevalonate kinase, EC 2.7.1.36, which transfers phosphate to position 5 of (R)-mevalonate and is part of the classical mevalonate pathway in eukaryotes and archaea.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Vinokur, J. M., Korman, T. P., Cao, Z., Bowie, J. U.
    Evidence of a novel mevalonate pathway in archaea.
    Biochemistry 53: 4161-4168 (2014). [PMID: 24914732]
  2. Azami, Y., Hattori, A., Nishimura, H., Kawaide, H., Yoshimura, T., Hemmi, H.
    (R)-mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum.
    J. Biol. Chem. 289: 15957-15967 (2014). [PMID: 24755225]

[EC 2.7.1.185 created 2014]