EC 2 - Transferases
EC 2.7 - Transferring phosphorus-containing groups
EC 2.7.1 - Phosphotransferases with an alcohol group as acceptor
EC 2.7.1.183 - Glycoprotein-mannosyl O6-kinase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.7.1.183
Names
Accepted name:
glycoprotein-mannosyl O6-kinase
Other
names:
SGK196
protein O-mannose kinase
protein O-mannose kinase
Systematic name:
ATP:O3-[N-acetyl-β-D-galactosaminyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→4)-α-D-mannosyl]-L-threonyl/L-seryl-[protein] 6-phosphotransferase
Reaction
- ATP + O3-[N-acetyl-beta-D-galactosaminyl-(1right3)-N-acetyl-beta-D-glucosaminyl-(1right4)-alpha-D-mannosyl]-L-threonyl/L-seryl-protein = ADP + O3-[N-acetyl-beta-D-galactosaminyl-(1right3)-N-acetyl-beta-D-glucosaminyl-(1right4)-alpha-D-(6-phospho)mannosyl]-L-threonyl/L-seryl-protein
Comments:
In humans this phosphorylated trisaccharide is attached to an L-threonine residue of α-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and is important for its activity.
Links to other databases
UniProtKB/Swiss-Prot:
SG196_CHICK
SG196_DANRE
SG196_HUMAN
SG196_MACFA
SG196_MOUSE
SG196_RAT
SG196_XENLA
References
-
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.Science 341 : 896-899 (2013). [PMID: 23929950]
[EC 2.7.1.183 created 2014]