EC 18.104.22.168 - Glycoprotein-mannosyl O6-kinase
IntEnz Enzyme Nomenclature
protein O-mannose kinase
- ATP + O3-[N-acetyl-beta-D-galactosaminyl-(1right3)-N-acetyl-beta-D-glucosaminyl-(1right4)-alpha-D-mannosyl]-L-threonyl/L-seryl-protein = ADP + O3-[N-acetyl-beta-D-galactosaminyl-(1right3)-N-acetyl-beta-D-glucosaminyl-(1right4)-alpha-D-(6-phospho)mannosyl]-L-threonyl/L-seryl-protein
In humans this phosphorylated trisaccharide is attached to an L-threonine residue of α-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and is important for its activity.
Links to other databases
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.Science 341 : 896-899 (2013). [PMID: 23929950]
[EC 22.214.171.124 created 2014]