EC 2.7.1.174 - Diacylglycerol kinase (CTP)

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.7.1.174

Names

Accepted name:
diacylglycerol kinase (CTP)
Other names:
DAG kinase
diglyceride kinase [ambiguous]
CTP-dependent diacylglycerol kinase
DGK1 (gene name)
diacylglycerol kinase (CTP dependent)
Systematic name:
CTP:1,2-diacyl-sn-glycerol 3-phosphotransferase

Reaction

Cofactor

Comments:

Requires Ca2+ or Mg2+ for activity. Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. Unlike the diacylglycerol kinases from bacteria, plants, and animals [cf. EC 2.7.1.107, diacylglycerol kinase (ATP)], the enzyme from Saccharomyces cerevisiae utilizes CTP. The enzyme can also use dCTP, but not ATP, GTP or UTP.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Han, G. S., O'Hara, L., Carman, G. M., Siniossoglou, S.
    An unconventional diacylglycerol kinase that regulates phospholipid synthesis and nuclear membrane growth.
    J. Biol. Chem. 283: 20433-20442 (2008). [PMID: 18458075]
  2. Han, G. S., O'Hara, L., Siniossoglou, S., Carman, G. M.
    Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase.
    J. Biol. Chem. 283: 20443-20453 (2008). [PMID: 18458076]
  3. Fakas, S., Konstantinou, C., Carman, G. M.
    DGK1-encoded diacylglycerol kinase activity is required for phospholipid synthesis during growth resumption from stationary phase in Saccharomyces cerevisiae.
    J. Biol. Chem. 286: 1464-1474 (2011). [PMID: 21071438]

[EC 2.7.1.174 created 2012, modified 2013]