EC 184.108.40.206 - Glycerate 2-kinase
IntEnz Enzyme Nomenclature
glycerate kinase (2-phosphoglycerate forming)
- ATP + D-glycerate = ADP + 2-phospho-D-glycerate
A key enzyme in the nonphosphorylative Entner-Doudoroff pathway in archaea [1,2]. In Hyphomicrobium methylovorum GM2 the enzyme is involved in formaldehyde assaimilation I (serine pathway) . In Escherichia coli the enzyme is involved in D-glucarate/D-galactarate degradation . The enzyme requires a divalent metal ion .
Links to other databases
A MOFRL family glycerate kinase from the thermophilic crenarchaeon, Sulfolobus tokodaii, with unique enzymatic properties.Biotechnol. Lett. 31 : 1937-1941 (2009). [PMID: 19690808]
Characterization of glycerate kinase (2-phosphoglycerate forming), a key enzyme of the nonphosphorylative Entner-Doudoroff pathway, from the thermoacidophilic euryarchaeon Picrophilus torridus.FEMS Microbiol. Lett. 259 : 113-119 (2006). [PMID: 16684110]
A unique highly thermostable 2-phosphoglycerate forming glycerate kinase from the hyperthermophilic archaeon Pyrococcus horikoshii: gene cloning, expression and characterization.Extremophiles 11 : 733-739 (2007). [PMID: 17563835]
Purification and characterization of glycerate kinase from the thermoacidophilic archaeon Thermoplasma acidophilum: an enzyme belonging to the second glycerate kinase family.Biotechnol. Bioprocess Eng. 11 : 344-350 (2006).
Purification and characterization of glycerate kinase from a serine-producing methylotroph, Hyphomicrobium methylovorum GM2.Eur. J. Biochem. 210 : 849-854 (1992). [PMID: 1336459]
Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli.Biochemistry 37 : 14369-14375 (1998). [PMID: 9772162]
[EC 220.127.116.11 created 2010]