EC 2.7.1.165 - Glycerate 2-kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.165

Names

Accepted name:
glycerate 2-kinase
Other names:
D-glycerate-2-kinase
glycerate kinase (2-phosphoglycerate forming)
Systematic name:
ATP:D-glycerate 2-phosphotransferase

Reaction

Cofactor

Comments:

A key enzyme in the nonphosphorylative Entner-Doudoroff pathway in archaea [1,2]. In Hyphomicrobium methylovorum GM2 the enzyme is involved in formaldehyde assaimilation I (serine pathway) [5]. In Escherichia coli the enzyme is involved in D-glucarate/D-galactarate degradation [6]. The enzyme requires a divalent metal ion [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00706
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043798
UniProtKB/Swiss-Prot:

References

  1. Liu, B., Wu, L., Liu, T., Hong, Y., Shen, Y., Ni, J.
    A MOFRL family glycerate kinase from the thermophilic crenarchaeon, Sulfolobus tokodaii, with unique enzymatic properties.
    Biotechnol. Lett. 31 : 1937-1941 (2009). [PMID: 19690808]
  2. Reher, M., Bott, M., Schonheit, P.
    Characterization of glycerate kinase (2-phosphoglycerate forming), a key enzyme of the nonphosphorylative Entner-Doudoroff pathway, from the thermoacidophilic euryarchaeon Picrophilus torridus.
    FEMS Microbiol. Lett. 259 : 113-119 (2006). [PMID: 16684110]
  3. Liu, B., Hong, Y., Wu, L., Li, Z., Ni, J., Sheng, D., Shen, Y.
    A unique highly thermostable 2-phosphoglycerate forming glycerate kinase from the hyperthermophilic archaeon Pyrococcus horikoshii: gene cloning, expression and characterization.
    Extremophiles 11 : 733-739 (2007). [PMID: 17563835]
  4. Noh, M., Jung, J.H. and Lee, S.B.
    Purification and characterization of glycerate kinase from the thermoacidophilic archaeon Thermoplasma acidophilum: an enzyme belonging to the second glycerate kinase family.
    Biotechnol. Bioprocess Eng. 11 : 344-350 (2006).
  5. Yoshida, T., Fukuta, K., Mitsunaga, T., Yamada, H., Izumi, Y.
    Purification and characterization of glycerate kinase from a serine-producing methylotroph, Hyphomicrobium methylovorum GM2.
    Eur. J. Biochem. 210 : 849-854 (1992). [PMID: 1336459]
  6. Hubbard, B. K., Koch, M., Palmer, D. R., Babbitt, P. C., Gerlt, J. A.
    Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli.
    Biochemistry 37 : 14369-14375 (1998). [PMID: 9772162]

[EC 2.7.1.165 created 2010]