IntEnz

EC 2.7.1.151 - Inositol-polyphosphate multikinase

IntEnz Enzyme Nomenclature
EC 2.7.1.151

Names

Reaction

• 32359 [IUBMB]
  1D-myo-inositol 1,4,5-trisphosphate

  1D-myo-inositol 1,4,5-trisphosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:203600

  Formula: C6H9O15P3
  Charge: -6

  ChEBI compound status: CHECKED (C)

  

  +

  2

  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  =

  1D-myo-inositol 1,3,4,5,6-pentakisphosphate

  1D-myo-inositol 1,3,4,5,6-pentakisphosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:57733

  Formula: C6H7O21P5
  Charge: -10

  ChEBI compound status: CHECKED (C)

  

  +

  2

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  2

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Comments:

This enzyme also phosphorylates Ins(1,4,5)P₃ to Ins(1,3,4,5)P₄, Ins(1,3,4,5)P₄ to Ins(1,3,4,5,6)P₅, and Ins(1,3,4,5,6)P₄ to Ins(PP)P₄, isomer unknown. The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P₄ and Ins(1,2,3,4,6)P₅ at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP₆), respectively [3]. Yeast produces InsP₆ from Ins(1,4,5)P₃ by the actions of this enzyme and EC 2.7.1.158, inositol-pentakisphosphate 2-kinase [4].

Links to other databases

References

1. Saiardi, A., Erdjument-Bromage, H., Snowman, A.M., Tempst, P. and Snyder, S.H.
   Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.
   Curr. Biol. 9: 1323-1326 (1999). [PMID: 10574768]
2. Odom, A.R., Stahlberg, A., Wente, S.R. and York, J.D.
   A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.
   Science 287: 2026-2029 (2000). [PMID: 10720331]
3. Stevenson-Paulik, J., Odom, A.R. and York, J.D.
   Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.
   J. Biol. Chem. 277: 42711-42718 (2002). [PMID: 12226109]
4. Verbsky, J.W., Chang, S.-C., Wilson, M.P., Mochizuki, Y. and Majerus, P.W.
   The pathway for the production of inositol hexakisphosphate in human cells.
   J. Biol. Chem. 280: 1911-1920 (2005). [PMID: 15531582]

[EC 2.7.1.151 created 2002, modified 2006]