IntEnz

EC 2.7.1.151 - Inositol-polyphosphate multikinase

IntEnz Enzyme Nomenclature
EC 2.7.1.151

Names

Reaction

• 32359 [IUBMB]
  1D-myo-inositol 1,4,5-trisphosphate

  1D-myo-inositol 1,4,5-trisphosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:203600

  Formula: C6H9O15P3
  Charge: -6

  ChEBI compound status: CHECKED (C)

  

  +

  2

  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  =

  1D-myo-inositol 1,3,4,5,6-pentakisphosphate

  1D-myo-inositol 1,3,4,5,6-pentakisphosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:57733

  Formula: C6H7O21P5
  Charge: -10

  ChEBI compound status: CHECKED (C)

  

  +

  2

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  2

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Comments:

This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown. The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P4 and Ins(1,2,3,4,6)P5 at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP6), respectively [3]. Yeast produces InsP6 from Ins(1,4,5)P3 by the actions of this enzyme and EC 2.7.1.158, inositol-pentakisphosphate 2-kinase [4].

Links to other databases

References

1. Saiardi, A., Erdjument-Bromage, H., Snowman, A.M., Tempst, P. and Snyder, S.H.
   Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.
   Curr. Biol. 9 : 1323-1326 (1999). [PMID: 10574768]
2. Odom, A.R., Stahlberg, A., Wente, S.R. and York, J.D.
   A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.
   Science 287 : 2026-2029 (2000). [PMID: 10720331]
3. Stevenson-Paulik, J., Odom, A.R. and York, J.D.
   Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.
   J. Biol. Chem. 277 : 42711-42718 (2002). [PMID: 12226109]
4. Verbsky, J.W., Chang, S.-C., Wilson, M.P., Mochizuki, Y. and Majerus, P.W.
   The pathway for the production of inositol hexakisphosphate in human cells.
   J. Biol. Chem. 280 : 1911-1920 (2005). [PMID: 15531582]

[EC 2.7.1.151 created 2002, modified 2006]