EC 2 - Transferases
EC 2.7 - Transferring phosphorus-containing groups
EC 2.7.1 - Phosphotransferases with an alcohol group as acceptor
EC 2.7.1.151 - Inositol-polyphosphate multikinase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.7.1.151
Names
Accepted name:
inositol-polyphosphate multikinase
Other
names:
IpK2
IP3/IP4 6-/3-kinase
IP3/IP4 dual-specificity 6-/3-kinase
IpmK
ArgRIII
AtIpk2α
AtIpk2β
inositol polyphosphate 6-/3-/5-kinase
IP3/IP4 6-/3-kinase
IP3/IP4 dual-specificity 6-/3-kinase
IpmK
ArgRIII
AtIpk2α
AtIpk2β
inositol polyphosphate 6-/3-/5-kinase
Systematic name:
ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase
Reactions
- (1) 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
- (1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
- (1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
Comments:
This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown. The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P4 and Ins(1,2,3,4,6)P5 at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP6), respectively [3]. Yeast produces InsP6 from Ins(1,4,5)P3 by the actions of this enzyme and EC 2.7.1.158, inositol-pentakisphosphate 2-kinase [4].
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0000823
,
GO:0050516
References
-
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.Curr. Biol. 9 : 1323-1326 (1999). [PMID: 10574768]
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A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.Science 287 : 2026-2029 (2000). [PMID: 10720331]
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Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.J. Biol. Chem. 277 : 42711-42718 (2002). [PMID: 12226109]
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The pathway for the production of inositol hexakisphosphate in human cells.J. Biol. Chem. 280 : 1911-1920 (2005). [PMID: 15531582]
[EC 2.7.1.151 created 2002, modified 2006]