EC - Inositol-polyphosphate multikinase

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IntEnz Enzyme Nomenclature


Accepted name:
inositol-polyphosphate multikinase
Other names:
IP3/IP4 6-/3-kinase
IP3/IP4 dual-specificity 6-/3-kinase
inositol polyphosphate 6-/3-/5-kinase
Systematic name:
ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase



This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown. The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P4 and Ins(1,2,3,4,6)P5 at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP6), respectively [3]. Yeast produces InsP6 from Ins(1,4,5)P3 by the actions of this enzyme and EC, inositol-pentakisphosphate 2-kinase [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0000823 , GO:0050516
UniProtKB/Swiss-Prot: (10) [show] [UniProt]


  1. Saiardi, A., Erdjument-Bromage, H., Snowman, A.M., Tempst, P. and Snyder, S.H.
    Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.
    Curr. Biol. 9 : 1323-1326 (1999). [PMID: 10574768]
  2. Odom, A.R., Stahlberg, A., Wente, S.R. and York, J.D.
    A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.
    Science 287 : 2026-2029 (2000). [PMID: 10720331]
  3. Stevenson-Paulik, J., Odom, A.R. and York, J.D.
    Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.
    J. Biol. Chem. 277 : 42711-42718 (2002). [PMID: 12226109]
  4. Verbsky, J.W., Chang, S.-C., Wilson, M.P., Mochizuki, Y. and Majerus, P.W.
    The pathway for the production of inositol hexakisphosphate in human cells.
    J. Biol. Chem. 280 : 1911-1920 (2005). [PMID: 15531582]

[EC created 2002, modified 2006]