IntEnz - EC 2.7.1.149

EC 2 - Transferases

EC 2.7 - Transferring phosphorus-containing groups

EC 2.7.1 - Phosphotransferases with an alcohol group as acceptor

EC 2.7.1.149 - 1-phosphatidylinositol-5-phosphate 4-kinase

IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.7.1.149

Names

Accepted name:

1-phosphatidylinositol-5-phosphate 4-kinase

Other name:

type II PIP kinase

Systematic name:

ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase

Reaction

12280 [IUBMB]

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)

Name origin: UniProt - CHECKED (C)

CHEBI:57795

Formula: C11H15O16P2R2
Charge: -3

ChEBI compound status: CHECKED (C)

+

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

=

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

Name origin: UniProt - CHECKED (C)

CHEBI:58456

Formula: C11H14O19P3R2
Charge: -5

ChEBI compound status: CHECKED (C)

+

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0016309

UniProtKB/Swiss-Prot: (16) [show] [UniProt]

References

Rameh, L.E., Tolias, K.F., Duckworth, B.C. and Cantley, L.C.

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.

Nature 390: 192-196 (1997). [PMID: 9367159]

[EC 2.7.1.149 created 2002]