EC 2 - Transferases
EC 2.7 - Transferring phosphorus-containing groups
EC 2.7.1 - Phosphotransferases with an alcohol group as acceptor
EC 2.7.1.148 - 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.7.1.148
Names
Accepted name:
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
Other
name:
CDP-ME kinase
Systematic name:
ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase
Reaction
- ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Cofactor
Comments:
The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0050515
ISPE_ACAM1
ISPE_ACET2
ISPE_ACIAC
ISPE_ACIAD
ISPE_ACIB3
ISPE_ACIB5
ISPE_ACIBC
ISPE_ACIBT
ISPE_ACIET
ISPE_ACISJ
ISPE_ACTP2
ISPE_ACTP7
ISPE_ACTPJ
ISPE_ACTSZ
ISPE_AERHH
ISPE_AERS4
ISPE_AGRFC
ISPE_ALCBS
ISPE_ALIF1
ISPE_ALIFM
ISPE_ALISL
ISPE_ALKEH
ISPE_ALKHC
ISPE_ALKMQ
ISPE_ALKOO
ISPE_ANAD2
ISPE_ANADE
ISPE_ANADF
ISPE_ANAMF
ISPE_ANAMM
ISPE_ANAPZ
ISPE_ANASK
ISPE_AQUAE
ISPE_ARATH
ISPE_AROAE
ISPE_ARTS2
ISPE_AZOC5
ISPE_AZOPC
ISPE_AZOSB
ISPE_BACAA
ISPE_BACAC
ISPE_BACAH
ISPE_BACAN
ISPE_BACC0
ISPE_BACC1
ISPE_BACC2
ISPE_BACC3
ISPE_BACC4
ISPE_BACC7
ISPE_BACCN
ISPE_BACCQ
ISPE_BACCR
ISPE_BACCZ
ISPE_BACFN
ISPE_BACFR
ISPE_BACHK
ISPE_BACLD
ISPE_BACMK
ISPE_BACP2
ISPE_BACSK
ISPE_BACSU
ISPE_BACTN
ISPE_BACVZ
ISPE_BARBK
ISPE_BARHE
ISPE_BARQU
ISPE_BART1
ISPE_BAUCH
ISPE_BIFAA
ISPE_BIFLD
ISPE_BIFLO
ISPE_BIFLS
ISPE_BLOPB
ISPE_BORBR
ISPE_BORPA
ISPE_BORPE
ISPE_BRADU
ISPE_BRASB
ISPE_BRASO
ISPE_BREBN
ISPE_BRUA2
ISPE_BRUAB
ISPE_BRUME
ISPE_BRUSU
ISPE_BUCAI
ISPE_BUCAP
ISPE_BURA4
ISPE_BURCA
ISPE_BURCC
ISPE_BURCH
ISPE_BURCJ
ISPE_BURCM
ISPE_BURL3
ISPE_BURM1
ISPE_BURM7
ISPE_BURM9
ISPE_BURMA
ISPE_BURMS
ISPE_BURP0
ISPE_BURP1
ISPE_BURP6
ISPE_BURPS
ISPE_BURTA
ISPE_BURVG
ISPE_CALBD
ISPE_CALS4
ISPE_CALS8
ISPE_CAMJ8
ISPE_CAMJD
ISPE_CAMJE
ISPE_CAMJJ
ISPE_CAMJR
ISPE_CARHZ
ISPE_CAUSK
ISPE_CAUVC
ISPE_CAUVN
ISPE_CELJU
ISPE_CERS4
ISPE_CERS5
ISPE_CHESB
ISPE_CHLAB
ISPE_CHLCH
ISPE_CHLCV
ISPE_CHLFF
ISPE_CHLL2
ISPE_CHLL3
ISPE_CHLMU
ISPE_CHLP8
ISPE_CHLPB
ISPE_CHLPD
ISPE_CHLPM
ISPE_CHLT2
ISPE_CHLT3
ISPE_CHLTA
ISPE_CHLTB
ISPE_CHLTE
ISPE_CHLTR
ISPE_CHRSD
ISPE_CHRVO
ISPE_CITBB
ISPE_CITK8
ISPE_CLAM3
ISPE_CLAMS
ISPE_CLOAB
ISPE_CLOB1
ISPE_CLOB6
ISPE_CLOB8
ISPE_CLOBA
ISPE_CLOBB
ISPE_CLOBH
ISPE_CLOBJ
ISPE_CLOBK
ISPE_CLOBL
ISPE_CLOBM
ISPE_CLOD6
ISPE_CLOK1
ISPE_CLOK5
ISPE_CLONN
ISPE_CLOP1
ISPE_CLOPE
ISPE_CLOPS
ISPE_CLOTE
ISPE_COLP3
ISPE_CORDI
ISPE_COREF
ISPE_CORGB
ISPE_CORGL
ISPE_CORJK
ISPE_CROS8
ISPE_CUPMC
ISPE_CUPNH
ISPE_CUPPJ
ISPE_CUPTR
ISPE_CUTAK
ISPE_CYAP4
ISPE_CYTH3
ISPE_DECAR
ISPE_DEHM1
ISPE_DEHMB
ISPE_DEHMC
ISPE_DEIGD
ISPE_DEIRA
ISPE_DELAS
ISPE_DESAG
ISPE_DESHD
ISPE_DESHY
ISPE_DESMR
ISPE_DESPS
ISPE_DESRM
ISPE_DESVH
ISPE_DESVV
ISPE_DINSH
ISPE_ECO24
ISPE_ECO27
ISPE_ECO45
ISPE_ECO55
ISPE_ECO57
ISPE_ECO5E
ISPE_ECO7I
ISPE_ECO81
ISPE_ECO8A
ISPE_ECOBW
ISPE_ECODH
ISPE_ECOHS
ISPE_ECOK1
ISPE_ECOL5
ISPE_ECOL6
ISPE_ECOLC
ISPE_ECOLI
ISPE_ECOLU
ISPE_ECOSE
ISPE_ECOSM
ISPE_ECOUT
ISPE_EHRCJ
ISPE_EHRCR
ISPE_EHRRG
ISPE_EHRRW
ISPE_ENT38
ISPE_ENTFA
ISPE_ERWT9
ISPE_ERYLH
ISPE_ESCF3
ISPE_EXIS2
ISPE_FERNB
ISPE_FINM2
ISPE_FRAP2
ISPE_FRAT1
ISPE_FRATF
ISPE_FRATH
ISPE_FRATM
ISPE_FRATN
ISPE_FRATO
ISPE_FRATT
ISPE_FRATW
ISPE_FUSNN
ISPE_GEODF
ISPE_GEOKA
ISPE_GEOMG
ISPE_GEOSL
ISPE_GEOSM
ISPE_GEOSW
ISPE_GEOTN
ISPE_GEOUR
ISPE_GLOC7
ISPE_GLOVI
ISPE_GLUDA
ISPE_GLUOX
ISPE_GRABC
ISPE_HAEDU
ISPE_HAEI8
ISPE_HAEIN
ISPE_HAES1
ISPE_HAHCH
ISPE_HALHL
ISPE_HAMD5
ISPE_HELAH
ISPE_HELMI
ISPE_HELPH
ISPE_HELPJ
ISPE_HELPY
ISPE_HERAR
ISPE_HISS2
ISPE_HYDS0
ISPE_HYPNA
ISPE_IDILO
ISPE_JANMA
ISPE_JANSC
ISPE_KINRD
ISPE_KLEP3
ISPE_KLEP7
ISPE_LACE2
ISPE_LACP7
ISPE_LACPL
ISPE_LATSS
ISPE_LAWIP
ISPE_LEIXX
ISPE_LEPBA
ISPE_LEPBP
ISPE_LEPIC
ISPE_LEPIN
ISPE_LEVBA
ISPE_LIGS1
ISPE_LIMF3
ISPE_LIMRD
ISPE_LIMRJ
ISPE_LISIN
ISPE_LISMC
ISPE_LISMF
ISPE_LISMH
ISPE_LISMO
ISPE_LISW6
ISPE_MACCJ
ISPE_MAGMM
ISPE_MAGSA
ISPE_MANSM
ISPE_MARMS
ISPE_MARN8
ISPE_MENPI
ISPE_METC4
ISPE_METCA
ISPE_METEP
ISPE_METFK
ISPE_METI4
ISPE_METPB
ISPE_METPP
ISPE_METRJ
ISPE_MICAN
ISPE_MOOTA
ISPE_MYCA1
ISPE_MYCBO
ISPE_MYCBP
ISPE_MYCBT
ISPE_MYCGI
ISPE_MYCLB
ISPE_MYCLE
ISPE_MYCMM
ISPE_MYCPA
ISPE_MYCS2
ISPE_MYCTA
ISPE_MYCTO
ISPE_MYCTU
ISPE_MYCUA
ISPE_MYCVP
ISPE_NEIG1
ISPE_NEIG2
ISPE_NEIM0
ISPE_NEIMA
ISPE_NEIMB
ISPE_NEIMF
ISPE_NEOSM
ISPE_NITEC
ISPE_NITEU
ISPE_NITHX
ISPE_NITMU
ISPE_NITOC
ISPE_NITWN
ISPE_NOCFA
ISPE_NOCSJ
ISPE_NOSP7
ISPE_NOSS1
ISPE_NOVAD
ISPE_OCEIH
ISPE_ORYSJ
ISPE_PAEAT
ISPE_PARD8
ISPE_PARDP
ISPE_PARL1
ISPE_PARMW
ISPE_PARP8
ISPE_PARPJ
ISPE_PARUW
ISPE_PARXL
ISPE_PASMU
ISPE_PECAS
ISPE_PECCP
ISPE_PEDPA
ISPE_PELPB
ISPE_PELPD
ISPE_PELTS
ISPE_PELUB
ISPE_PERMH
ISPE_PETMO
ISPE_PHOLL
ISPE_PHOPR
ISPE_PHOV8
ISPE_POLAQ
ISPE_POLNA
ISPE_POLNS
ISPE_POLSJ
ISPE_PORG3
ISPE_PORGI
ISPE_PROA2
ISPE_PROM0
ISPE_PROM1
ISPE_PROM2
ISPE_PROM3
ISPE_PROM5
ISPE_PROM9
ISPE_PROMA
ISPE_PROMH
ISPE_PROMM
ISPE_PROMP
ISPE_PROMS
ISPE_PROMT
ISPE_PSE14
ISPE_PSEA6
ISPE_PSEA7
ISPE_PSEA8
ISPE_PSEAB
ISPE_PSEAE
ISPE_PSECP
ISPE_PSEE4
ISPE_PSEF5
ISPE_PSEFS
ISPE_PSELT
ISPE_PSEMY
ISPE_PSEP1
ISPE_PSEPF
ISPE_PSEPG
ISPE_PSEPK
ISPE_PSEPW
ISPE_PSESM
ISPE_PSET1
ISPE_PSEU2
ISPE_PSEU5
ISPE_PSYA2
ISPE_PSYCK
ISPE_PSYIN
ISPE_PSYWF
ISPE_RALPJ
ISPE_RALSO
ISPE_RHIE6
ISPE_RHIEC
ISPE_RHIL3
ISPE_RHILO
ISPE_RHILW
ISPE_RHIME
ISPE_RHOBA
ISPE_RHOFT
ISPE_RHOJR
ISPE_RHOP2
ISPE_RHOP5
ISPE_RHOPA
ISPE_RHOPB
ISPE_RHOPS
ISPE_RHORT
ISPE_RHOS1
ISPE_RHOSK
ISPE_ROSDO
ISPE_RUBXD
ISPE_RUEPO
ISPE_RUTMC
ISPE_SACD2
ISPE_SACEN
ISPE_SALA4
ISPE_SALAI
ISPE_SALAR
ISPE_SALCH
ISPE_SALEP
ISPE_SALG2
ISPE_SALHS
ISPE_SALPA
ISPE_SALPB
ISPE_SALPC
ISPE_SALPK
ISPE_SALRD
ISPE_SALSV
ISPE_SALTI
ISPE_SALTO
ISPE_SALTY
ISPE_SERP5
ISPE_SHEAM
ISPE_SHEB2
ISPE_SHEB5
ISPE_SHEB8
ISPE_SHEB9
ISPE_SHEDO
ISPE_SHEFN
ISPE_SHEHH
ISPE_SHELP
ISPE_SHEON
ISPE_SHEPA
ISPE_SHEPC
ISPE_SHEPW
ISPE_SHESA
ISPE_SHESH
ISPE_SHESM
ISPE_SHESR
ISPE_SHESW
ISPE_SHEWM
ISPE_SHIB3
ISPE_SHIBS
ISPE_SHIDS
ISPE_SHIF8
ISPE_SHIFL
ISPE_SHISS
ISPE_SINMW
ISPE_SODGM
ISPE_SOLLC
ISPE_SOLUE
ISPE_SPHAL
ISPE_SPHWW
ISPE_STAA1
ISPE_STAA2
ISPE_STAA3
ISPE_STAA8
ISPE_STAA9
ISPE_STAAB
ISPE_STAAC
ISPE_STAAE
ISPE_STAAM
ISPE_STAAN
ISPE_STAAR
ISPE_STAAS
ISPE_STAAW
ISPE_STAEQ
ISPE_STAES
ISPE_STAHJ
ISPE_STAS1
ISPE_STRA1
ISPE_STRA3
ISPE_STRA5
ISPE_STRAW
ISPE_STRCO
ISPE_STRE4
ISPE_STREM
ISPE_STRMU
ISPE_STRS7
ISPE_STRU0
ISPE_SULDN
ISPE_SULNB
ISPE_SULSY
ISPE_SYMTH
ISPE_SYNAS
ISPE_SYNC1
ISPE_SYNE7
ISPE_SYNFM
ISPE_SYNJA
ISPE_SYNJB
ISPE_SYNP2
ISPE_SYNP6
ISPE_SYNPW
ISPE_SYNR3
ISPE_SYNS3
ISPE_SYNS9
ISPE_SYNSC
ISPE_SYNWW
ISPE_SYNY3
ISPE_THEAB
ISPE_THEFY
ISPE_THEM4
ISPE_THEMA
ISPE_THEP1
ISPE_THEP3
ISPE_THEPX
ISPE_THESQ
ISPE_THET2
ISPE_THET8
ISPE_THEVB
ISPE_THEYD
ISPE_THIDA
ISPE_TOLAT
ISPE_TREDE
ISPE_TREPA
ISPE_TREPS
ISPE_TRIEI
ISPE_TRIV2
ISPE_TROW8
ISPE_TROWT
ISPE_UREP2
ISPE_UREPA
ISPE_UREU1
ISPE_VARPS
ISPE_VEREI
ISPE_VESOH
ISPE_VIBA3
ISPE_VIBC3
ISPE_VIBCB
ISPE_VIBCH
ISPE_VIBCM
ISPE_VIBPA
ISPE_VIBVU
ISPE_VIBVY
ISPE_WIGBR
ISPE_WOLPM
ISPE_WOLTR
ISPE_WOLWR
ISPE_XANAC
ISPE_XANC5
ISPE_XANC8
ISPE_XANCB
ISPE_XANCP
ISPE_XANOM
ISPE_XANOR
ISPE_XANP2
ISPE_XYLFA
ISPE_XYLFT
ISPE_YERP3
ISPE_YERPA
ISPE_YERPB
ISPE_YERPE
ISPE_YERPG
ISPE_YERPN
ISPE_YERPP
ISPE_YERPS
ISPE_YERPY
ISPE_ZYMMO
References
-
Kuzuyama, T., Takagi, M., Kaneda, K., Watanabe, H., Dairi, T. and Seto, H.Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol to its 2-phospho derivative by 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase.Tetrahedron Lett. 41 : 2925-2928 (2000).
-
Lüttgen, H., Rohdich, F., Herz, S., Wungsintaweekul, J., Hecht, S., Schuhr, C.A., Fellermeier, M., Sagner, S., Zenk, M.H., Bacher, A. and Eisenreich, W.Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.Proc. Natl. Acad. Sci. USA 97 : 1062-1067 (2000). [PMID: 10655484]
[EC 2.7.1.148 created 2001]