EC 2.7.1.148 - 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.148

Names

Accepted name:
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
Other name:
CDP-ME kinase
Systematic name:
ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase

Reaction

Cofactor

Comments:

The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050515
UniProtKB/Swiss-Prot: (587) [show] [UniProt]

References

  1. Kuzuyama, T., Takagi, M., Kaneda, K., Watanabe, H., Dairi, T. and Seto, H.
    Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol to its 2-phospho derivative by 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase.
    Tetrahedron Lett. 41: 2925-2928 (2000).
  2. Lüttgen, H., Rohdich, F., Herz, S., Wungsintaweekul, J., Hecht, S., Schuhr, C.A., Fellermeier, M., Sagner, S., Zenk, M.H., Bacher, A. and Eisenreich, W.
    Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
    Proc. Natl. Acad. Sci. USA 97: 1062-1067 (2000). [PMID: 10655484]

[EC 2.7.1.148 created 2001]