IntEnz

EC 2.7.1.145 - Deoxynucleoside kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.145

Names

Accepted name:

deoxynucleoside kinase

Other names:

D. melanogaster deoxynucleoside kinase
Dm-dNK
ms-dNK
multifunctional deoxynucleoside kinase
multispecific deoxynucleoside kinase
multisubstrate deoxyribonucleoside kinase

Systematic name:

ATP:deoxyribonucleoside 5'-phosphotransferase

Reactions

12140 [IUBMB]

a 2'-deoxyribonucleoside

a 2'-deoxyribonucleoside

Name origin: UniProt - CHECKED (C)

CHEBI:18274

Formula: C5H9O3R
Charge: 0

ChEBI compound status: CHECKED (C)

+

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

=

a 2'-deoxyribonucleoside 5'-phosphate

a 2'-deoxyribonucleoside 5'-phosphate

Name origin: UniProt - CHECKED (C)

CHEBI:65317

Formula: C5H8O6PR
Charge: -2

ChEBI compound status: CHECKED (C)

+

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)
46040

2'-deoxycytidine

2'-deoxycytidine

Name origin: UniProt - CHECKED (C)

CHEBI:15698

Formula: C9H13N3O4
Charge: 0

ChEBI compound status: CHECKED (C)

+

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

=

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

dCMP

dCMP

Name origin: UniProt - CHECKED (C)

CHEBI:57566

Formula: C9H12N3O7P
Charge: -2

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)
23452

2'-deoxyadenosine

2'-deoxyadenosine

Name origin: UniProt - CHECKED (C)

CHEBI:17256

Formula: C10H13N5O3
Charge: 0

ChEBI compound status: CHECKED (C)

+

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

=

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

dAMP

dAMP

Name origin: UniProt - CHECKED (C)

CHEBI:58245

Formula: C10H12N5O6P
Charge: -2

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)
19201

2'-deoxyguanosine

2'-deoxyguanosine

Name origin: UniProt - CHECKED (C)

CHEBI:17172

Formula: C10H13N5O4
Charge: 0

ChEBI compound status: CHECKED (C)

+

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

=

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

dGMP

dGMP

Name origin: UniProt - CHECKED (C)

CHEBI:57673

Formula: C10H12N5O7P
Charge: -2

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)
19129

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

thymidine

thymidine

Name origin: UniProt - CHECKED (C)

CHEBI:17748

Formula: C10H14N2O5
Charge: 0

ChEBI compound status: CHECKED (C)

=

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

dTMP

dTMP

Name origin: UniProt - CHECKED (C)

CHEBI:63528

Formula: C10H13N2O8P
Charge: -2

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

Comments:

The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2'-deoxyribonucleoside kinases [EC 2.7.1.76 (deoxyadenosine kinase) and EC 2.7.1.113 (deoxyguanosine kinase)] in its broad specificity for all four common 2'-deoxyribonucleosides.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0019136

CAS Registry Number: 52227-81-3

UniProtKB/Swiss-Prot:

Q9XZT6

DNK_DROME

References

Munch-Petersen, B., Piskur, J. and Søndergaard, L.

Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase.

J. Biol. Chem. 273 : 3926-3931 (1998). [PMID: 9461577]
Munch-Petersen, B., Knecht, W., Lenz, C., Søndergaard, L. and Piskur, J.

Functional expression of a multisubstrate deoxyribonculeoside kinase from Drosophila melanogaster and its C-terminal deletion.

J. Biol. Chem. 275 : 6673-6679 (2000). [PMID: 10692477]

[EC 2.7.1.145 created 2001]

EC 2 - Transferases