EC 2.7.1.145 - Deoxynucleoside kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.145

Names

Accepted name:
deoxynucleoside kinase
Other names:
D. melanogaster deoxynucleoside kinase
Dm-dNK
ms-dNK
multifunctional deoxynucleoside kinase
multispecific deoxynucleoside kinase
multisubstrate deoxyribonucleoside kinase
Systematic name:
ATP:deoxyribonucleoside 5'-phosphotransferase

Reaction

Comments:

The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2'-deoxyribonucleoside kinases [EC 2.7.1.76 (deoxyadenosine kinase) and EC 2.7.1.113 (deoxyguanosine kinase)] in its broad specificity for all four common 2'-deoxyribonucleosides.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0019136
CAS Registry Number: 52227-81-3
UniProtKB/Swiss-Prot:

References

  1. Munch-Petersen, B., Piskur, J. and Søndergaard, L.
    Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase.
    J. Biol. Chem. 273 : 3926-3931 (1998). [PMID: 9461577]
  2. Munch-Petersen, B., Knecht, W., Lenz, C., Søndergaard, L. and Piskur, J.
    Functional expression of a multisubstrate deoxyribonculeoside kinase from Drosophila melanogaster and its C-terminal deletion.
    J. Biol. Chem. 275 : 6673-6679 (2000). [PMID: 10692477]

[EC 2.7.1.145 created 2001]