EC - Tetraacyldisaccharide 4'-kinase

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IntEnz Enzyme Nomenclature


Accepted name:
tetraacyldisaccharide 4'-kinase
Other name:
lipid-A 4'-kinase
Systematic name:
ATP:2,3,2',3'-tetrakis[(3R)-3-hydroxytetradecanoyl]-β-D-glucosaminyl-(1→6)-α-D-glucosaminyl-phosphate 4'-O-phosphotransferase



Involved with EC (acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase) and EC (lipid-A-disaccharide synthase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0009029
CAS Registry Number: 107309-06-8
UniProtKB/Swiss-Prot: (376) [show] [UniProt]


  1. Ray, B.L. and Raetz C.R.H.
    The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4'-phosphate of lipid A.
    J. Biol. Chem. 262: 1122-1128 (1987). [PMID: 3027079]

[EC created 1990]