EC 2.7.1.119 - Hygromycin-B 7''-O-kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.119

Names

Accepted name:
hygromycin-B 7''-O-kinase
Other names:
hygromycin B phosphotransferase
APH(7'')
hygromycin-B kinase [ambiguous]
Systematic name:
ATP:hygromycin-B 7''-O-phosphotransferase

Reaction

Comments:

Phosphorylates the antibiotics hygromycin B, 1-N-hygromycin B and destomycin, but not hygromycin B2, at the 7''-hydroxy group in the destomic acid ring.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008904
CAS Registry Number: 88361-67-5
UniProtKB/Swiss-Prot:

References

  1. Zalacain, M., Pardo, J.M. and Jiménez, A.
    Purification and characterization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus.
    Eur. J. Biochem. 162: 419-422 (1987). [PMID: 3026811]

[EC 2.7.1.119 created 1989, modified 2009, modified 2011]