IntEnz

EC 2.7.1.107 - Diacylglycerol kinase (ATP)

IntEnz Enzyme Nomenclature
EC 2.7.1.107

Names

Reaction

• 10272 [IUBMB]
  a 1,2-diacyl-sn-glycerol

  a 1,2-diacyl-sn-glycerol

  Name origin: UniProt - CHECKED (C)

  CHEBI:17815

  Formula: C5H6O5R2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  =

  a 1,2-diacyl-sn-glycero-3-phosphate

  a 1,2-diacyl-sn-glycero-3-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:58608

  Formula: C5H5O8PR2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Comments:

Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. Activity is stimulated by certain phospholipids [4,7]. In plants and animals the product 1,2-diacyl-sn-glycerol 3-phosphate is an important second messenger. cf. EC 2.7.1.174, diacylglycerol kinase (CTP).

Links to other databases

References

1. Daleo, G.R., Piras, M.M. and Piras, R.
   Diglyceride kinase activity of microtubules. Characterization and comparison with the protein kinase and ATPase activities associated with vinblastine-isolated tubulin of chick embryonic muscles.
   Eur. J. Biochem. 68 : 339-346 (1976). [PMID: 185051]
2. Hokin, L.E. and Hokin, M.R.
   Diglyceride kinase and other pathways for phosphatidic acid synthesis in the erythrocyte membrane.
   Biochim. Biophys. Acta 67 : 470-484 (1963). [PMID: 13961253]
3. Weissbach, H., Thomas, E. and Kaback, H.R.
   Studies on the metabolism of ATP by isolated bacterial membranes: formation and metabolism of membrane-bound phosphatidic acid.
   Arch. Biochem. Biophys. 147 : 249-254 (1971). [PMID: 4940043]
4. Walsh, J. P., Bell, R. M.
   sn-1,2-Diacylglycerol kinase of Escherichia coli. Structural and kinetic analysis of the lipid cofactor dependence.
   J. Biol. Chem. 261 : 15062-15069 (1986). [PMID: 3021764]
5. Russ, E., Kaiser, U., Sandermann, H.
   Lipid-dependent membrane enzymes. Purification to homogeneity and further characterization of diacylglycerol kinase from Escherichia coli.
   Eur. J. Biochem. 171 : 335-342 (1988). [PMID: 2828054]
6. Walsh, J. P., Bell, R. M.
   Diacylglycerol kinase from Escherichia coli.
   Meth. Enzymol. 209 : 153-162 (1992). [PMID: 1323028]
7. Wissing, J. B., Wagner, K. G.
   Diacylglycerol kinase from suspension cultured plant cells : characterization and subcellular localization.
   Plant Physiol. 98 : 1148-1153 (1992). [PMID: 16668739]

[EC 2.7.1.107 created 1984, modified 2013]