EC - Hexokinase

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
ATP-dependent hexokinase
glucose ATP phosphotransferase
hexokinase (phosphorylating)
hexokinase D
hexokinase type IV
hexokinase type IV glucokinase
hexokinase type I
hexokinase type II
hexokinase type III
Systematic name:
ATP:D-hexose 6-phosphotransferase



D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00370
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004396
CAS Registry Number: 9001-51-8
UniProtKB/Swiss-Prot: (73) [show] [UniProt]


  1. Bailey, K. and Webb, E.C.
    Purification of yeast hexokinase and its reaction with ββ'-dichlorodiethyl sulphide.
    Biochem. J. 42 : 60-68 (1948). [PMID: 16748250]
  2. Berger, L., Slein, M.W., Colowick, S.P. and Cori, C.F.
    Isolation of hexokinase from baker's yeast.
    J. Gen. Physiol. 29 : 379-391 (1946).
  3. Kunitz, M. and McDonald, M.R.
    Crystalline hexokinase (heterophosphatase). Method of isolation and properties.
    J. Gen. Physiol. 29 : 393-412 (1946).
  4. Pollard-Knight, D. and Cornish-Bowden, A.
    Mechanism of liver glucokinase.
    Mol. Cell. Biochem. 44 : 71-80 (1982). [PMID: 7048063]
  5. Ureta, T., Radojkovic, J., Lagos, R., Guixe, V. and Núñez, L.
    Phylogenetic and ontogenetic studies of glucose phosphorylating isozymes of vertebrates.
    Arch. Biol. Med. Exp. 12 : 587-604 (1979). [PMID: 233226]
  6. Cárdenas, M.L., Rabajille, E. and Niemeyer, H.
    Fructose: A good substrate for rat-liver 'glucokinase' (hexokinase D).
    Biochem. J. 222 : 363-370 (1984). [PMID: 6477520]

[EC created 1961]