IntEnz

EC 2.7.1.1 - Hexokinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.1

Names

Accepted name:

hexokinase

Other names:

ATP-dependent hexokinase
glucose ATP phosphotransferase
hexokinase (phosphorylating)
hexokinase D
hexokinase type IV
hexokinase type IV glucokinase
hexokinase type I
hexokinase type II
hexokinase type III

Systematic name:

ATP:D-hexose 6-phosphotransferase

Reactions

22740 [IUBMB]

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

D-hexose

D-hexose

Name origin: UniProt - CHECKED (C)

CHEBI:4194

Formula: C6H12O6
Charge: 0

ChEBI compound status: CHECKED (C)

=

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

D-hexose 6-phosphate

D-hexose 6-phosphate

Name origin: UniProt - CHECKED (C)

CHEBI:61567

Formula: C6H11O9P
Charge: -2

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)
17825

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

D-glucose

D-glucose

Name origin: UniProt - CHECKED (C)

CHEBI:4167

Formula: C6H12O6
Charge: 0

ChEBI compound status: CHECKED (C)

=

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

D-glucose 6-phosphate

D-glucose 6-phosphate

Name origin: UniProt - CHECKED (C)

CHEBI:61548

Formula: C6H11O9P
Charge: -2

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)
16125

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

D-fructose

D-fructose

Name origin: UniProt - CHECKED (C)

CHEBI:37721

Formula: C6H12O6
Charge: 0

ChEBI compound status: CHECKED (C)

=

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

D-fructose 6-phosphate

D-fructose 6-phosphate

Name origin: UniProt - CHECKED (C)

CHEBI:61527

Formula: C6H11O9P
Charge: -2

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)
11028

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

D-mannose

D-mannose

Name origin: UniProt - CHECKED (C)

CHEBI:4208

Formula: C6H12O6
Charge: 0

ChEBI compound status: CHECKED (C)

=

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

D-mannose 6-phosphate

D-mannose 6-phosphate

Name origin: UniProt - CHECKED (C)

CHEBI:58735

Formula: C6H11O9P
Charge: -2

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)
10948

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

D-glucosamine

D-glucosamine

Name origin: UniProt - CHECKED (C)

CHEBI:58723

Formula: C6H14NO5
Charge: 1

ChEBI compound status: CHECKED (C)

=

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

D-glucosamine 6-phosphate

D-glucosamine 6-phosphate

Name origin: UniProt - CHECKED (C)

CHEBI:58725

Formula: C6H13NO8P
Charge: -1

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

Comments:

D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway

Protein domains and families: PROSITE:PDOC00370

Structural data: CSA , EC2PDB

Gene Ontology: GO:0004396

CAS Registry Number: 9001-51-8

UniProtKB/Swiss-Prot: (73) [show] [UniProt]

References

Bailey, K. and Webb, E.C.

Purification of yeast hexokinase and its reaction with ββ'-dichlorodiethyl sulphide.

Biochem. J. 42 : 60-68 (1948). [PMID: 16748250]
Berger, L., Slein, M.W., Colowick, S.P. and Cori, C.F.

Isolation of hexokinase from baker's yeast.

J. Gen. Physiol. 29 : 379-391 (1946).
Kunitz, M. and McDonald, M.R.

Crystalline hexokinase (heterophosphatase). Method of isolation and properties.

J. Gen. Physiol. 29 : 393-412 (1946).
Pollard-Knight, D. and Cornish-Bowden, A.

Mechanism of liver glucokinase.

Mol. Cell. Biochem. 44 : 71-80 (1982). [PMID: 7048063]
Ureta, T., Radojkovic, J., Lagos, R., Guixe, V. and Núñez, L.

Phylogenetic and ontogenetic studies of glucose phosphorylating isozymes of vertebrates.

Arch. Biol. Med. Exp. 12 : 587-604 (1979). [PMID: 233226]
Cárdenas, M.L., Rabajille, E. and Niemeyer, H.

Fructose: A good substrate for rat-liver 'glucokinase' (hexokinase D).

Biochem. J. 222 : 363-370 (1984). [PMID: 6477520]

[EC 2.7.1.1 created 1961]

EC 2 - Transferases