EC 2 - Transferases
EC 2.7 - Transferring phosphorus-containing groups
EC 2.7.1 - Phosphotransferases with an alcohol group as acceptor
EC 2.7.1.1 - Hexokinase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.7.1.1
Names
Accepted name:
hexokinase
Other
names:
ATP-dependent hexokinase
glucose ATP phosphotransferase
hexokinase (phosphorylating)
hexokinase D
hexokinase type IV
hexokinase type IV glucokinase
hexokinase type I
hexokinase type II
hexokinase type III
glucose ATP phosphotransferase
hexokinase (phosphorylating)
hexokinase D
hexokinase type IV
hexokinase type IV glucokinase
hexokinase type I
hexokinase type II
hexokinase type III
Systematic name:
ATP:D-hexose 6-phosphotransferase
Reaction
- ATP + D-hexose = ADP + D-hexose 6-phosphate
Comments:
D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
NIST 74
,
UniPathway
Protein domains and families:
PROSITE:PDOC00370
Gene Ontology:
GO:0004396
CAS Registry Number:
9001-51-8
References
-
Purification of yeast hexokinase and its reaction with ββ'-dichlorodiethyl sulphide.Biochem. J. 42 : 60-68 (1948). [PMID: 16748250]
-
Isolation of hexokinase from baker's yeast.J. Gen. Physiol. 29 : 379-391 (1946).
-
Crystalline hexokinase (heterophosphatase). Method of isolation and properties.J. Gen. Physiol. 29 : 393-412 (1946).
-
Mechanism of liver glucokinase.Mol. Cell. Biochem. 44 : 71-80 (1982). [PMID: 7048063]
-
Phylogenetic and ontogenetic studies of glucose phosphorylating isozymes of vertebrates.Arch. Biol. Med. Exp. 12 : 587-604 (1979). [PMID: 233226]
-
Fructose: A good substrate for rat-liver 'glucokinase' (hexokinase D).Biochem. J. 222 : 363-370 (1984). [PMID: 6477520]
[EC 2.7.1.1 created 1961]