EC 2.6.1.99 - L-tryptophan—pyruvate aminotransferase

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IntEnz Enzyme Nomenclature
EC 2.6.1.99

Names

Accepted name:
L-tryptophan—pyruvate aminotransferase
Other names:
TAA1 (gene name)
vt2 (gene name)
Systematic name:
L-tryptophan:pyruvate aminotransferase

Reaction

Comments:

This plant enzyme, along with EC 1.14.13.168, indole-3-pyruvate monooxygenase, is responsible for the biosynthesis of the plant hormone indole-3-acetate from L-tryptophan.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Tao, Y., Ferrer, J. L., Ljung, K., Pojer, F., Hong, F., Long, J. A., Li, L., Moreno, J. E., Bowman, M. E., Ivans, L. J., Cheng, Y., Lim, J., Zhao, Y., Ballare, C. L., Sandberg, G., Noel, J. P., Chory, J.
    Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants.
    Cell 133 : 164-176 (2008). [PMID: 18394996]
  2. Mashiguchi, K., Tanaka, K., Sakai, T., Sugawara, S., Kawaide, H., Natsume, M., Hanada, A., Yaeno, T., Shirasu, K., Yao, H., McSteen, P., Zhao, Y., Hayashi, K., Kamiya, Y., Kasahara, H.
    The main auxin biosynthesis pathway in Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A. 108 : 18512-18517 (2011). [PMID: 22025724]
  3. Phillips, K. A., Skirpan, A. L., Liu, X., Christensen, A., Slewinski, T. L., Hudson, C., Barazesh, S., Cohen, J. D., Malcomber, S., McSteen, P.
    vanishing tassel2 encodes a grass-specific tryptophan aminotransferase required for vegetative and reproductive development in maize.
    Plant Cell 23 : 550-566 (2011). [PMID: 21335375]
  4. Zhao, Y.
    Auxin biosynthesis: a simple two-step pathway converts tryptophan to indole-3-acetic acid in plants.
    Mol Plant 5 : 334-338 (2012). [PMID: 22155950]

[EC 2.6.1.99 created 2012]