EC 2.6.1.98 - UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase

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IntEnz Enzyme Nomenclature
EC 2.6.1.98

Names

Accepted name:
UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase
Other names:
WbpE
WlbC
Systematic name:
UDP-2-acetamido-3-amino-2,3-dideoxy-α-D-glucuronate:2-oxoglutarate aminotransferase

Reaction

Cofactor

Comments:

A pyridoxal 5'-phosphate protein. This enzyme participates in the biosynthetic pathway for UDP-α-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-α-D-mannuronic acid), an important precursor of B-band lipopolysaccharide. The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the previous enzyme in the pathway, EC 1.1.1.335 (UDP-N-acetyl-2-amino-2-deoxyglucuronate oxidase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Westman, E. L., McNally, D. J., Charchoglyan, A., Brewer, D., Field, R. A., Lam, J. S.
    Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa.
    J. Biol. Chem. 284: 11854-11862 (2009). [PMID: 19282284]
  2. Larkin, A., Imperiali, B.
    Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1.
    Biochemistry 48: 5446-5455 (2009). [PMID: 19348502]
  3. Larkin, A., Olivier, N. B., Imperiali, B.
    Structural analysis of WbpE from Pseudomonas aeruginosa PAO1: a nucleotide sugar aminotransferase involved in O-antigen assembly.
    Biochemistry 49: 7227-7237 (2010). [PMID: 20604544]

[EC 2.6.1.98 created 2012]