EC 2.6.1.95 - Neomycin C transaminase

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IntEnz Enzyme Nomenclature
EC 2.6.1.95

Names

Accepted name:
neomycin C transaminase
Other name:
neoN (gene name)
Systematic name:
2-oxoglutarate:neomycin C aminotransferase

Reaction

Comments:

The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC 1.1.3.44, 6'''-hydroxyneomycin C oxidase, to replace the 6'''-hydroxy group of 6'''-deamino-6'''-hydroxyneomycin C with an amino group. The enzyme, characterized from the bacterium Streptomyces fradiae, can also catalyse EC 2.6.1.93, neamine transaminase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Huang, F., Spiteller, D., Koorbanally, N. A., Li, Y., Llewellyn, N. M., Spencer, J. B.
    Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin.
    Chembiochem 8 : 283-288 (2007). [PMID: 17206729]
  2. Clausnitzer, D., Piepersberg, W., Wehmeier, U. F.
    The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin.
    J. Appl. Microbiol. 111 : 642-651 (2011). [PMID: 21689223]

[EC 2.6.1.95 created 2012]