EC - Kynurenine—oxoglutarate transaminase

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IntEnz Enzyme Nomenclature


Accepted name:
kynurenine—oxoglutarate transaminase
Other names:
L-kynurenine aminotransferase
kynurenine 2-oxoglutarate transaminase
kynurenine aminotransferase
kynurenine transaminase (cyclizing)
kynurenine—oxoglutarate aminotransferase
Systematic name:
L-kynurenine:2-oxoglutarate aminotransferase




A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016212
CAS Registry Number: 9030-38-0
UniProtKB/Swiss-Prot: (36) [show] [UniProt]


  1. Jakoby, W.B. and Bonner, D.M.
    Kynurenine transaminase from Neurospora.
    J. Biol. Chem. 221 : 689-695 (1956). [PMID: 13357462]
  2. Mason, M.
    Kynurenine transaminase of rat kidney: a study of coenzyme dissociation.
    J. Biol. Chem. 227 : 61-68 (1957). [PMID: 13449053]
  3. Noguchi, T., Minatogawa, Y., Okuno, E., Nakatani, M., Morimoto, M.
    Purification and characterization of kynurenine--2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats.
    Biochem. J. 151 : 399-406 (1975). [PMID: 1218085]
  4. Han, Q., Robinson, H., Cai, T., Tagle, D. A., Li, J.
    Biochemical and structural properties of mouse kynurenine aminotransferase III.
    Mol. Cell. Biol. 29 : 784-793 (2009). [PMID: 19029248]

[EC created 1961, modified 1983]