EC 2.6.1.6 - Leucine transaminase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.6.1.6
Names
Accepted name:
leucine transaminase
Other
names:
L-leucine aminotransferase
leucine 2-oxoglutarate transaminase
leucine aminotransferase
leucine—α-ketoglutarate transaminase
leucine 2-oxoglutarate transaminase
leucine aminotransferase
leucine—α-ketoglutarate transaminase
Systematic name:
L-leucine:2-oxoglutarate aminotransferase
Reaction
- L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
Cofactor
Comments:
A pyridoxal-phosphate protein. This enzyme differs from EC 2.6.1.42, branched-chain-amino-acid transaminase, in that it does not act on L-valine or L-isoleucine, although it does act on L-methionine. The mitochondrial form from rat liver differs in physical characteristics from the cytoplasmic form.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
DIAGRAM
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0050048
CAS Registry Number:
9030-37-9
References
-
Transaminases of branched chain amino acids. IV. Purification and properties of two enzymes from rat liver.Biochim. Biophys. Acta 159 : 276-284 (1968). [PMID: 4968655]
-
Transaminase of branched chain amino acids. XI. Leucine (methionine) transaminase of rat liver mitochondria.Biochim. Biophys. Acta 445 : 622-631 (1976). [PMID: 974100]
[EC 2.6.1.6 created 1961, modified 1982]