EC 2.6.1.6 - Leucine transaminase

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IntEnz Enzyme Nomenclature
EC 2.6.1.6

Names

Accepted name:
leucine transaminase
Other names:
L-leucine aminotransferase
leucine 2-oxoglutarate transaminase
leucine aminotransferase
leucine—α-ketoglutarate transaminase
Systematic name:
L-leucine:2-oxoglutarate aminotransferase

Reaction

Cofactor

Comments:

A pyridoxal-phosphate protein. This enzyme differs from EC 2.6.1.42, branched-chain-amino-acid transaminase, in that it does not act on L-valine or L-isoleucine, although it does act on L-methionine. The mitochondrial form from rat liver differs in physical characteristics from the cytoplasmic form.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050048
CAS Registry Number: 9030-37-9

References

  1. Aki, K., Ogawa, K. and Ichihara, A.
    Transaminases of branched chain amino acids. IV. Purification and properties of two enzymes from rat liver.
    Biochim. Biophys. Acta 159: 276-284 (1968). [PMID: 4968655]
  2. Ikeda, T., Konishi, Y. and Ichihara, A.
    Transaminase of branched chain amino acids. XI. Leucine (methionine) transaminase of rat liver mitochondria.
    Biochim. Biophys. Acta 445: 622-631 (1976). [PMID: 974100]

[EC 2.6.1.6 created 1961, modified 1982]