IntEnz

EC 2.6.1.57 - Aromatic-amino-acid transaminase

IntEnz Enzyme Nomenclature
EC 2.6.1.57

Names

Reactions

• 17533 [IUBMB]
  2-oxoglutarate

  2-oxoglutarate

  Name origin: UniProt - CHECKED (C)

  CHEBI:16810

  Formula: C5H4O5
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  an aromatic L-α-amino acid

  an aromatic L-alpha-amino acid

  Name origin: UniProt - CHECKED (C)

  CHEBI:84824

  Formula: C2H4NO2R
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  an aromatic oxo-acid

  an aromatic oxo-acid

  Name origin: UniProt - CHECKED (C)

  CHEBI:73309

  Formula: C2O3R
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  L-glutamate

  L-glutamate

  Name origin: UniProt - CHECKED (C)

  CHEBI:29985

  Formula: C5H8NO4
  Charge: -1

  ChEBI compound status: CHECKED (C)

  
• 25796
  2-oxoglutarate

  2-oxoglutarate

  Name origin: UniProt - CHECKED (C)

  CHEBI:16810

  Formula: C5H4O5
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  L-methionine

  L-methionine

  Name origin: UniProt - CHECKED (C)

  CHEBI:57844

  Formula: C5H11NO2S
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  4-methylsulfanyl-2-oxobutanoate

  4-methylsulfanyl-2-oxobutanoate

  Name origin: UniProt - CHECKED (C)

  CHEBI:16723

  Formula: C5H7O3S
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  L-glutamate

  L-glutamate

  Name origin: UniProt - CHECKED (C)

  CHEBI:29985

  Formula: C5H8NO4
  Charge: -1

  ChEBI compound status: CHECKED (C)

  
• 15093
  2-oxoglutarate

  2-oxoglutarate

  Name origin: UniProt - CHECKED (C)

  CHEBI:16810

  Formula: C5H4O5
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  L-tyrosine

  L-tyrosine

  Name origin: UniProt - CHECKED (C)

  CHEBI:58315

  Formula: C9H11NO3
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  3-(4-hydroxyphenyl)pyruvate

  3-(4-hydroxyphenyl)pyruvate

  Name origin: UniProt - CHECKED (C)

  CHEBI:36242

  Formula: C9H7O4
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  L-glutamate

  L-glutamate

  Name origin: UniProt - CHECKED (C)

  CHEBI:29985

  Formula: C5H8NO4
  Charge: -1

  ChEBI compound status: CHECKED (C)

  
• 25152
  2-oxoglutarate

  2-oxoglutarate

  Name origin: UniProt - CHECKED (C)

  CHEBI:16810

  Formula: C5H4O5
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  L-phenylalanine

  L-phenylalanine

  Name origin: UniProt - CHECKED (C)

  CHEBI:58095

  Formula: C9H11NO2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  3-phenylpyruvate

  3-phenylpyruvate

  Name origin: UniProt - CHECKED (C)

  CHEBI:18005

  Formula: C9H7O3
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  L-glutamate

  L-glutamate

  Name origin: UniProt - CHECKED (C)

  CHEBI:29985

  Formula: C5H8NO4
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

Cofactor

• pyridoxal 5'-phosphate

Comments:

A pyridoxal-phosphate protein. L-Methionine can also act as donor, but more slowly; oxaloacetate can act as acceptor. Controlled proteolysis converts the enzyme into EC 2.6.1.1 aspartate transaminase.

Links to other databases

References

1. Mavrides, C. and Orr, W.
   Multispecific aspartate and aromatic amino acid aminotransferases in Escherichia coli.
   J. Biol. Chem. 250: 4128-4133 (1975). [PMID: 236311]

[EC 2.6.1.57 created 1976]