EC 2.6.1.34 - UDP-N-acetylbacillosamine transaminase

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IntEnz Enzyme Nomenclature
EC 2.6.1.34

Names

Accepted name:
UDP-N-acetylbacillosamine transaminase
Other names:
uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase
UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose transaminase
UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase
UDP-4-amino-4,6-dideoxy-N-acetyl-α-D-glucosamine transaminase
pglE (gene name)
Systematic name:
UDP-4-amino-4,6-dideoxy-N-acetyl-α-D-glucosamine:2-oxoglutarate aminotransferase

Reaction

Cofactor

Comments:

A pyridoxal-phosphate protein. The enzyme is involved in biosynthesis of UDP-N,N'-diacetylbacillosamine, an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species [2-4] and O-linked glycosylation of certain L-serine residues in Neisseria species [5].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047302
CAS Registry Number: 37277-89-7
UniProtKB/Swiss-Prot:

References

  1. Distier, J., Kaufman, B. and Roseman, S.
    Enzymic synthesis of a diamino sugar nucleotide by extracts of type XIV Diplococcus pneumoniae.
    Arch. Biochem. Biophys. 116 : 466-478 (1966). [PMID: 4381351]
  2. Olivier, N. B., Chen, M. M., Behr, J. R., Imperiali, B.
    In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system.
    Biochemistry 45 : 13659-13669 (2006). [PMID: 17087520]
  3. Schoenhofen, I. C., McNally, D. J., Vinogradov, E., Whitfield, D., Young, N. M., Dick, S., Wakarchuk, W. W., Brisson, J. R., Logan, S. M.
    Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways.
    J. Biol. Chem. 281 : 723-732 (2006). [PMID: 16286454]
  4. Rangarajan, E. S., Ruane, K. M., Sulea, T., Watson, D. C., Proteau, A., Leclerc, S., Cygler, M., Matte, A., Young, N. M.
    Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter jejuni.
    Biochemistry 47 : 1827-1836 (2008). [PMID: 18198901]
  5. Hartley, M. D., Morrison, M. J., Aas, F. E., Borud, B., Koomey, M., Imperiali, B.
    Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N'-diacetylbacillosamine.
    Biochemistry 50 : 4936-4948 (2011). [PMID: 21542610]

[EC 2.6.1.34 created 1972, modified 2013]