EC 2.6.1.23 - 4-hydroxyglutamate transaminase
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IntEnz Enzyme Nomenclature
EC 2.6.1.23
Names
Accepted name:
4-hydroxyglutamate transaminase
Other
name:
4-hydroxyglutamate aminotransferase
Systematic name:
erythro-4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase
Reaction
- erythro-4-hydroxy-L-glutamate + 2-oxoglutarate = (4R)-4-hydroxy-2-oxoglutarate + L-glutamate
Comments:
The enzyme participates in a degradation pathway of trans-4-hydroxy-L-proline, a compound that contributes to the stability of the collagen triple helix. Oxaloacetate can replace 2-oxoglutarate. This enzyme may be identical with EC 2.6.1.1 aspartate transaminase.
Links to other databases
Gene Ontology:
GO:0047578
CAS Registry Number:
37277-86-4
References
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Metabolism of γ-hydroxyglutamic acid. I. Conversion to α-hydroxy-γ-ketoglutarate by purified glutamic-aspartic transaminase to rat liver.J. Biol. Chem. 237 : 3476-3485 (1962). [PMID: 13948827]
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The metabolism of γ-hydroxyglutamate in rat liver. II. A transaminase concerned in γ-hydroxyglutamate metabolism.Biochim. Biophys. Acta 78 : 629-636 (1963). [PMID: 14089443]
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Purification of rat-liver γ-hydroxyglutmate transaminase and its probable identity with glutamate-aspartate transaminase.Biochim. Biophys. Acta 81 : 517-532 (1964). [PMID: 14170323]
[EC 2.6.1.23 created 1972, modified 1982, modified 2020]