IntEnz

EC 2.6.1.23 - 4-hydroxyglutamate transaminase

IntEnz Enzyme Nomenclature
EC 2.6.1.23

Names

Reaction

• 10480 [IUBMB]
  2-oxoglutarate

  2-oxoglutarate

  Name origin: UniProt - CHECKED (C)

  CHEBI:16810

  Formula: C5H4O5
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  4-hydroxy-L-glutamate

  4-hydroxy-L-glutamate

  Name origin: UniProt - CHECKED (C)

  CHEBI:32812

  Formula: C5H8NO5
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  =

  4-hydroxy-2-oxoglutarate

  4-hydroxy-2-oxoglutarate

  Name origin: UniProt - CHECKED (C)

  CHEBI:17742

  Formula: C5H4O6
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  L-glutamate

  L-glutamate

  Name origin: UniProt - CHECKED (C)

  CHEBI:29985

  Formula: C5H8NO4
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

Comments:

Oxaloacetate can replace 2-oxoglutarate. This enzyme may be identical with EC 2.6.1.1 aspartate transaminase.

Links to other databases

References

1. Goldstone, A. and Adams, E.
   Metabolism of γ-hydroxyglutamic acid. I. Conversion to α-hydroxy-γ-ketoglutarate by purified glutamic-aspartic transaminase to rat liver.
   J. Biol. Chem. 237: 3476-3485 (1962). [PMID: 13948827]
2. Kuratomi, K., Fukunaga, K. and Kobayashi, Y.
   The metabolism of γ-hydroxyglutamate in rat liver. II. A transaminase concerned in γ-hydroxyglutamate metabolism.
   Biochim. Biophys. Acta 78: 629-636 (1963).

[EC 2.6.1.23 created 1972, modified 1982]