EC - 4-hydroxyglutamate transaminase

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IntEnz Enzyme Nomenclature


Accepted name:
4-hydroxyglutamate transaminase
Other name:
4-hydroxyglutamate aminotransferase
Systematic name:
erythro-4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase



The enzyme participates in a degradation pathway of trans-4-hydroxy-L-proline, a compound that contributes to the stability of the collagen triple helix. Oxaloacetate can replace 2-oxoglutarate. This enzyme may be identical with EC aspartate transaminase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047578
CAS Registry Number: 37277-86-4


  1. Goldstone, A. and Adams, E.
    Metabolism of γ-hydroxyglutamic acid. I. Conversion to α-hydroxy-γ-ketoglutarate by purified glutamic-aspartic transaminase to rat liver.
    J. Biol. Chem. 237 : 3476-3485 (1962). [PMID: 13948827]
  2. Kuratomi, K., Fukunaga, K. and Kobayashi, Y.
    The metabolism of γ-hydroxyglutamate in rat liver. II. A transaminase concerned in γ-hydroxyglutamate metabolism.
    Biochim. Biophys. Acta 78 : 629-636 (1963). [PMID: 14089443]
  3. Maitra, U., Deeker, E.
    Purification of rat-liver γ-hydroxyglutmate transaminase and its probable identity with glutamate-aspartate transaminase.
    Biochim. Biophys. Acta 81 : 517-532 (1964). [PMID: 14170323]

[EC created 1972, modified 1982, modified 2020]