EC 2.6.1.19 - 4-aminobutyrate—2-oxoglutarate transaminase

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IntEnz Enzyme Nomenclature
EC 2.6.1.19

Names

Accepted name:
4-aminobutyrate—2-oxoglutarate transaminase
Other names:
4-aminobutyrate aminotransferase
4-aminobutyrate—2-ketoglutarate aminotransferase
4-aminobutyrate—2-oxoglutarate aminotransferase
4-aminobutyrate-2-oxoglutarate transaminase
4-aminobutyric acid 2-ketoglutaric acid aminotransferase
4-aminobutyric acid aminotransferase
β-alanine aminotransferase
β-alanine—oxoglutarate aminotransferase
β-alanine—oxoglutarate transaminase
γ-aminobutyrate aminotransaminase
γ-aminobutyrate transaminase
γ-aminobutyrate:α-oxoglutarate aminotransferase
γ-aminobutyrate—α-ketoglutarate aminotransferase
γ-aminobutyrate—α-ketoglutarate transaminase
γ-aminobutyric acid aminotransferase
γ-aminobutyric acid pyruvate transaminase
γ-aminobutyric acid transaminase
γ-aminobutyric acid—2-oxoglutarate transaminase
γ-aminobutyric acid—α-ketoglutarate transaminase
γ-aminobutyric acid—α-ketoglutaric acid aminotransferase
γ-aminobutyric transaminase
GABA aminotransferase
GABA transaminase
GABA transferase [ambiguous]
GABA—2-oxoglutarate aminotransferase
GABA—2-oxoglutarate transaminase
GABA—α-ketoglutarate aminotransferase
GABA—α-ketoglutarate transaminase
GABA—α-ketoglutaric acid transaminase
GABA—α-oxoglutarate aminotransferase
GABA—oxoglutarate aminotransferase
GABA—oxoglutarate transaminase
aminobutyrate aminotransferase
aminobutyrate transaminase
glutamate—succinic semialdehyde transaminase
γ-amino-N-butyrate transaminase
GabT
Systematic name:
4-aminobutanoate:2-oxoglutarate aminotransferase

Reaction

Cofactor

Comments:

Requires pyridoxal phosphate. Some preparations also act on β-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00519
Structural data: CSA , EC2PDB
Gene Ontology: GO:0034386
CAS Registry Number: 9037-67-6
UniProtKB/Swiss-Prot: (20) [show] [UniProt]

References

  1. Aurich, H.
    Über die β-Alanin-α-Ketoglutarat-Transaminase aus Neurospora crassa.
    Hoppe-Seyler's Z. Physiol. Chem. 326 : 25-33 (1961).
  2. Schausboe, A., Wu, J.-Y. and Roberts, E.
    Purification and characterization of the 4-aminobutyrate-2-ketoglutarate transaminase from mouse brain.
    Biochemistry 12 : 2868-2873 (1973). [PMID: 4719123]
  3. Scott, E.M. and Jakoby, W.B.
    Soluble γ-aminobutyric-glutamic transaminase from Pseudomonas fluorescens.
    J. Biol. Chem. 234 : 932-936 (1959). [PMID: 13654294]
  4. Bartsch, K., von Johnn-Marteville, A., Schulz, A.
    Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD).
    J. Bacteriol. 172 : 7035-7042 (1990). [PMID: 2254272]

[EC 2.6.1.19 created 1965, modified 1982, modified 2012]