EC 2.6.1.114 - 8-demethyl-8-aminoriboflavin-5'-phosphate synthase

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IntEnz Enzyme Nomenclature
EC 2.6.1.114

Names

Accepted name:
8-demethyl-8-aminoriboflavin-5'-phosphate synthase
Other name:
rosB (gene name)
Systematic name:
L-glutamate:FMN aminotransferase (oxidizing, decarboxylating)

Reaction

Comments:

The enzyme, characterized from the bacterium Streptomyces davawensis, has the activities of an oxidoreductase, a decarboxylase, and an aminotransferase. Its combined actions result in the replacement of a methyl substituent of one of the aromatic rings of FMN by an amino group, a step in the biosynthetic pathway of roseoflavin. The reaction requires thiamine for completion.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Schwarz, J., Konjik, V., Jankowitsch, F., Sandhoff, R., Mack, M.
    Identification of the Key Enzyme of Roseoflavin Biosynthesis.
    Angew. Chem. Int. Ed. Engl. 55: 6103-6106 (2016). [PMID: 27062037]
  2. Jhulki, I., Chanani, P. K., Abdelwahed, S. H., Begley, T. P.
    A Remarkable Oxidative Cascade That Replaces the Riboflavin C8 Methyl with an Amino Group during Roseoflavin Biosynthesis.
    J. Am. Chem. Soc. 138: 8324-8327 (2016). [PMID: 27331868]
  3. Konjik, V., Brunle, S., Demmer, U., Vanselow, A., Sandhoff, R., Ermler, U., Mack, M.
    The Crystal Structure of RosB: Insights into the Reaction Mechanism of the First Member of a Family of Flavodoxin-like Enzymes.
    Angew. Chem. Int. Ed. Engl. 56: 1146-1151 (2017). [PMID: 27981706]

[EC 2.6.1.114 created 2018]