EC 2.6.1.103 - (S)-3,5-dihydroxyphenylglycine transaminase

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IntEnz Enzyme Nomenclature
EC 2.6.1.103

Names

Accepted name:
(S)-3,5-dihydroxyphenylglycine transaminase
Other name:
HpgT
Systematic name:
(S)-3,5-dihydroxyphenylglycine:2-oxoglutarate aminotransferase

Reaction

Cofactor

Comments:

A pyridoxal-5'-phosphate protein. The enzyme from the bacterium Amycolatopsis orientalis catalyses the reaction in the reverse direction as part of the biosynthesis of the (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Sandercock, A.M., Charles, E.H., Scaife, W., Kirkpatrick, P.N., O'Brien, S.W., Papageorgiou, E.A., Spencer, J.B. and Williams, D.H.
    Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin.
    Chem. Comm. 1252-1253 (2001).

[EC 2.6.1.103 created 2013]