EC 2.6.1.102 - GDP-perosamine synthase

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IntEnz Enzyme Nomenclature
EC 2.6.1.102

Names

Accepted name:
GDP-perosamine synthase
Other names:
RfbE
GDP-4-keto-6-deoxy-D-mannose-4-aminotransferase
GDP-perosamine synthetase
PerA
Systematic name:
GDP-4-amino-4,6-dideoxy-α-D-mannose:2-oxoglutarate aminotransferase

Reaction

Cofactor

Comments:

A pyridoxal 5'-phosphate enzyme. D-Perosamine is one of several dideoxy sugars found in the O-specific polysaccharide of the lipopolysaccharide component of the outer membrane of Gram-negative bacteria. The enzyme catalyses the final step in GDP-perosamine synthesis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102933
UniProtKB/Swiss-Prot:

References

  1. Albermann, C., Piepersberg, W.
    Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
    Glycobiology 11: 655-661 (2001). [PMID: 11479276]
  2. Zhao, G., Liu, J., Liu, X., Chen, M., Zhang, H., Wang, P. G.
    Cloning and characterization of GDP-perosamine synthetase (Per) from Escherichia coli O157:H7 and synthesis of GDP-perosamine in vitro.
    Biochem. Biophys. Res. Commun. 363: 525-530 (2007). [PMID: 17888872]
  3. Albermann, C., Beuttler, H.
    Identification of the GDP-N-acetyl-d-perosamine producing enzymes from Escherichia coli O157:H7.
    FEBS Lett. 582: 479-484 (2008). [PMID: 18201574]
  4. Cook, P. D., Carney, A. E., Holden, H. M.
    Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase.
    Biochemistry 47: 10685-10693 (2008). [PMID: 18795799]

[EC 2.6.1.102 created 2013]