EC 2.6.1.100 - L-glutamine:2-deoxy-scyllo-inosose aminotransferase

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IntEnz Enzyme Nomenclature
EC 2.6.1.100

Names

Accepted name:
L-glutamine:2-deoxy-scyllo-inosose aminotransferase
Other names:
btrR (gene name)
neoB (gene name)
kanB (gene name)
Systematic name:
L-glutamine:2-deoxy-scyllo-inosose aminotransferase

Reaction

Comments:

Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Also catalyses EC 2.6.1.101, L-glutamine:5-amino-2,3,4-trihydroxycyclohexanone aminotransferase [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Tamegai, H., Eguchi, T., Kakinuma, K.
    First identification of Streptomyces genes involved in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics--genetic and evolutionary analysis of L-glutamine:2-deoxy-scyllo-inosose aminotransferase genes.
    J. Antibiot. 55: 1016-1018 (2002). [PMID: 12546424]
  2. Huang, F., Haydock, S. F., Mironenko, T., Spiteller, D., Li, Y., Spencer, J. B.
    The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine.
    Org. Biomol. Chem. 3: 1410-1418 (2005). [PMID: 15827636]
  3. Kudo, F., Yamamoto, Y., Yokoyama, K., Eguchi, T., Kakinuma, K.
    Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773.
    J. Antibiot. 58: 766-774 (2005). [PMID: 16506694]
  4. Jnawali, H. N., Subba, B., Liou, K., Sohng, J. K.
    Functional characterization of kanB by complementing in engineered Streptomyces fradiae Deltaneo6::tsr.
    Biotechnol. Lett. 31: 869-875 (2009). [PMID: 19219581]

[EC 2.6.1.100 created 2013]