EC - 4,4'-diapophytoene synthase

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IntEnz Enzyme Nomenclature


Accepted name:
4,4'-diapophytoene synthase
Other names:
dehydrosqualene synthase
DAP synthase
C30 carotene synthase
Systematic name:
farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase (4,4'-diapophytoene forming)




Requires Mn2+. Typical of Staphylococcus aureus and some other bacteria such as Heliobacillus sp.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Umeno, D., Tobias, A. V., Arnold, F. H.
    Evolution of the C30 carotenoid synthase CrtM for function in a C40 pathway.
    J. Bacteriol. 184: 6690-6699 (2002). [PMID: 12426357]
  2. Pelz, A., Wieland, K. P., Putzbach, K., Hentschel, P., Albert, K., Gotz, F.
    Structure and biosynthesis of staphyloxanthin from Staphylococcus aureus.
    J. Biol. Chem. 280: 32493-32498 (2005). [PMID: 16020541]
  3. Ku, B., Jeong, J. C., Mijts, B. N., Schmidt-Dannert, C., Dordick, J. S.
    Preparation, characterization, and optimization of an in vitro C30 carotenoid pathway.
    Appl. Environ. Microbiol. 71: 6578-6583 (2005). [PMID: 16269684]
  4. Liu, C. I., Liu, G. Y., Song, Y., Yin, F., Hensler, M. E., Jeng, W. Y., Nizet, V., Wang, A. H., Oldfield, E.
    A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
    Science 319: 1391-1394 (2008). [PMID: 18276850]

[EC created 2011]