EC 2.5.1.90 - all-trans-octaprenyl-diphosphate synthase

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IntEnz Enzyme Nomenclature
EC 2.5.1.90

Names

Accepted name:
all-trans-octaprenyl-diphosphate synthase
Other names:
octaprenyl-diphosphate synthase
octaprenyl pyrophosphate synthetase
polyprenylpyrophosphate synthetase
terpenoidallyltransferase
terpenyl pyrophosphate synthetase
trans-heptaprenyltranstransferase
trans-prenyltransferase
Systematic name:
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 5 isopentenyl units)

Reaction

Comments:

This enzyme catalyses the condensation reactions resulting in the formation of all-trans-octaprenyl diphosphate, the isoprenoid side chain of ubiquinone-8 and menaquinone-8. The enzyme adds five isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Fujisaki, S., Nishino, T., Katsuki, H.
    Isoprenoid synthesis in Escherichia coli. Separation and partial purification of four enzymes involved in the synthesis.
    J. Biochem. 99 : 1327-1337 (1986). [PMID: 3519603]
  2. Asai, K., Fujisaki, S., Nishimura, Y., Nishino, T., Okada, K., Nakagawa, T., Kawamukai, M., Matsuda, H.
    The identification of Escherichia coli ispB (cel) gene encoding the octaprenyl diphosphate synthase.
    Biochem. Biophys. Res. Commun. 202 : 340-345 (1994). [PMID: 8037730]

[EC 2.5.1.90 created 2010]