EC - Riboflavin synthase

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IntEnz Enzyme Nomenclature


Accepted name:
riboflavin synthase
Other names:
heavy riboflavin synthase
light riboflavin synthase
riboflavin synthetase
riboflavine synthase
riboflavine synthetase
Systematic name:
6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase



A flavoprotein (riboflavin).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00581
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004746
CAS Registry Number: 9075-82-5
UniProtKB/Swiss-Prot: (27) [show] [UniProt]


  1. Plaut, G.W.E.
    Studies on the nature of the enzymic conversion of 6,7-dimethyl-8-ribityllumazine to riboflavin.
    J. Biol. Chem. 238 : 2225-2243 (1963).
  2. Plaut, G.W.E. and Harvey, R.A.
    Riboflavin synthetase.
    Methods Enzymol. 18B : 527-538 (1971).
  3. Wacker, H., Harvey, R.A., Winestock, C.H. and Plaut, G.W.E.
    4-(1'-D-Ribitylamino)-5-amino-2,6-dihydroxypyrimidine, the second product of the riboflavin synthetase reaction.
    J. Biol. Chem. 239 : 3493-3497 (1964).

[EC created 1972]