EC 2.5.1.89 - tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]

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IntEnz Enzyme Nomenclature
EC 2.5.1.89

Names

Accepted name:
tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]
Systematic name:
geranylgeranyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 7 isopentenyl units)

Reaction

Comments:

This enzyme is involved in the biosynthesis of the glycosyl carrier lipid in some archaebacteria. Unlike EC 2.5.1.31, its counterpart in most bacteria, it prefers geranylgeranyl diphosphate to farnesyl diphosphate as the allylic substrate, resulting in production of a tritrans,polycis variant of undecaprenyl diphosphate [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (20) [show] [UniProt]

References

  1. Hemmi, H., Yamashita, S., Shimoyama, T., Nakayama, T., Nishino, T.
    Cloning, expression, and characterization of cis-polyprenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus acidocaldarius.
    J. Bacteriol. 183: 401-404 (2001). [PMID: 11114943]

[EC 2.5.1.89 created 2010, modified 2011]