EC - trans,polycis-decaprenyl diphosphate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
trans,polycis-decaprenyl diphosphate synthase
Other names:
(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate synthase
Systematic name:
(2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesylcistransferase (adding 7 isopentenyl units)



The enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Kaur, D., Brennan, P. J., Crick, D. C.
    Decaprenyl diphosphate synthesis in Mycobacterium tuberculosis.
    J. Bacteriol. 186 : 7564-7570 (2004). [PMID: 15516568]
  2. Wang, W., Dong, C., McNeil, M., Kaur, D., Mahapatra, S., Crick, D. C., Naismith, J. H.
    The structural basis of chain length control in Rv1086.
    J. Mol. Biol. 381 : 129-140 (2008). [PMID: 18597781]
  3. Crick, D. C., Schulbach, M. C., Zink, E. E., Macchia, M., Barontini, S., Besra, G. S., Brennan, P. J.
    Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis.
    J. Bacteriol. 182 : 5771-5778 (2000). [PMID: 11004176]

[EC created 2010]