EC 2.5.1.85 - all-trans-nonaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]

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IntEnz Enzyme Nomenclature
EC 2.5.1.85

Names

Accepted name:
all-trans-nonaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]
Other names:
nonaprenyl diphosphate synthase
solanesyl diphosphate synthetase
solanesyl diphosphate synthase
At-SPS2
At-SPS1
SPS1
SPS2
Systematic name:
geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 5 isopentenyl units)

Reaction

Comments:

Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate [1]. The plant Arabidopsis thaliana has two different enzymes that catalyse this reaction. SPS1 contributes to the biosynthesis of the ubiquinone side-chain while SPS2 supplies the precursor of the plastoquinone side-chains [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052924 , GO:0050347
UniProtKB/Swiss-Prot:

References

  1. Hirooka, K., Bamba, T., Fukusaki, E., Kobayashi, A.
    Cloning and kinetic characterization of Arabidopsis thaliana solanesyl diphosphate synthase.
    Biochem. J. 370: 679-686 (2003). [PMID: 12437513]
  2. Hirooka, K., Izumi, Y., An, C. I., Nakazawa, Y., Fukusaki, E., Kobayashi, A.
    Functional analysis of two solanesyl diphosphate synthases from Arabidopsis thaliana.
    Biosci. Biotechnol. Biochem. 69: 592-601 (2005). [PMID: 15784989]
  3. Jun, L., Saiki, R., Tatsumi, K., Nakagawa, T., Kawamukai, M.
    Identification and subcellular localization of two solanesyl diphosphate synthases from Arabidopsis thaliana.
    Plant Cell Physiol. 45: 1882-1888 (2004). [PMID: 15653808]

[EC 2.5.1.85 created 1972 as EC 2.5.1.11, part-transferred 2010 to EC 2.5.1.85]