EC 2.5.1.83 - Hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]

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IntEnz Enzyme Nomenclature
EC 2.5.1.83

Names

Accepted name:
hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
Other names:
HexPS [ambiguous]
hexaprenyl pyrophosphate synthetase [ambiguous]
hexaprenyl diphosphate synthase [ambiguous]
Systematic name:
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units)

Reaction

Comments:

The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0036423
UniProtKB/Swiss-Prot:

References

  1. Fujii, H., Koyama, T., Ogura, K.
    Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components.
    J. Biol. Chem. 257: 14610-14612 (1982). [PMID: 7174655]
  2. Shimizu, N., Koyama, T., Ogura, K.
    Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase.
    J. Bacteriol. 180: 1578-1581 (1998). [PMID: 9515931]
  3. Nagaki, M., Kimura, K., Kimura, H., Maki, Y., Goto, E., Nishino, T., Koyama, T.
    Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases.
    Bioorg. Med. Chem. Lett. 11: 2157-2159 (2001). [PMID: 11514159]

[EC 2.5.1.83 created 1984 as EC 2.5.1.33, part-transferred 2010 to EC 2.5.1.83]