EC 2.5.1.82 - Hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]

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IntEnz Enzyme Nomenclature
EC 2.5.1.82

Names

Accepted name:
hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
Other names:
(all-trans)-hexaprenyl-diphosphate synthase
hexaprenyl diphosphate synthase [ambiguous]
hexaprenyl pyrophosphate synthetase [ambiguous]
HexPS [ambiguous]
(all-E) hexaprenyl diphosphate synthase
HexPPs [ambiguous]
Systematic name:
geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units)

Reaction

Cofactor

Comments:

The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate. Requires Mg2+ [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052922
CAS Registry Number: 83745-07-7
UniProtKB/Swiss-Prot:

References

  1. Hemmi, H., Ikejiri, S., Yamashita, S., Nishino, T.
    Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus.
    J. Bacteriol. 184 : 615-620 (2002). [PMID: 11790729]
  2. Hemmi, H., Noike, M., Nakayama, T., Nishino, T.
    Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations.
    Biochem. Biophys. Res. Commun. 297 : 1096-1101 (2002). [PMID: 12372398]
  3. Sun, H. Y., Ko, T. P., Kuo, C. J., Guo, R. T., Chou, C. C., Liang, P. H., Wang, A. H.
    Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures.
    J. Bacteriol. 187 : 8137-8148 (2005). [PMID: 16291686]

[EC 2.5.1.82 created 1984 as EC 2.5.1.33, part-transferred 2010 to EC 2.5.1.82]