EC 2 - Transferases
EC 2.5 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1.82 - Hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.5.1.82
Names
Accepted name:
hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
Other
names:
(all-trans)-hexaprenyl-diphosphate synthase
hexaprenyl diphosphate synthase [ambiguous]
hexaprenyl pyrophosphate synthetase [ambiguous]
HexPS [ambiguous]
(all-E) hexaprenyl diphosphate synthase
HexPPs [ambiguous]
hexaprenyl diphosphate synthase [ambiguous]
hexaprenyl pyrophosphate synthetase [ambiguous]
HexPS [ambiguous]
(all-E) hexaprenyl diphosphate synthase
HexPPs [ambiguous]
Systematic name:
geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units)
Reaction
-
27555 [IUBMB]all-trans-geranylgeranyl diphosphateName origin: UniProt - CHECKED (C)Formula: C20H33O7P2
Charge: -3ChEBI compound status: CHECKED (C)2isopentenyl diphosphateName origin: UniProt - CHECKED (C)Formula: C5H9O7P2
Charge: -3ChEBI compound status: CHECKED (C)=all-trans-hexaprenyl diphosphateName origin: UniProt - CHECKED (C)Formula: C30H49O7P2
Charge: -3ChEBI compound status: CHECKED (C)2
Cofactor
Comments:
The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate. Requires Mg2+ [1].
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ERGO
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0052922
CAS Registry Number:
83745-07-7
UniProtKB/Swiss-Prot:
HEXPP_SACS2
References
-
Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus.J. Bacteriol. 184: 615-620 (2002). [PMID: 11790729]
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Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations.Biochem. Biophys. Res. Commun. 297: 1096-1101 (2002). [PMID: 12372398]
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Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures.J. Bacteriol. 187: 8137-8148 (2005). [PMID: 16291686]
[EC 2.5.1.82 created 1984 as EC 2.5.1.33, part-transferred 2010 to EC 2.5.1.82]