EC - Geranylfarnesyl diphosphate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
geranylfarnesyl diphosphate synthase
Other names:
FGPP synthase
(all-E) geranylfarnesyl diphosphate synthase
Systematic name:
geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 1 isopentenyl unit)



The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis. It prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate [1]. The enzyme from Aeropyrum pernix prefers farnesyl diphosphate as allylic substrate. The enzyme is involved in the biosynthesis of C25-C25 membrane lipids [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0044687


  1. Ogawa, T., Yoshimura, T., Hemmi, H.
    Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution.
    Biochem. Biophys. Res. Commun. 393 : 16-20 (2010). [PMID: 20097171]
  2. Tachibana, A., Yano, Y., Otani, S., Nomura, N., Sako, Y., Taniguchi, M.
    Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon, Aeropyrum pernix. Molecular evolution with alteration in product specificity.
    Eur. J. Biochem. 267 : 321-328 (2000). [PMID: 10632701]
  3. Tachibana, A.
    A novel prenyltransferase, farnesylgeranyl diphosphate synthase, from the haloalkaliphilic archaeon, Natronobacterium pharaonis.
    FEBS Lett. 341 : 291-294 (1994). [PMID: 8137956]
  4. Lee, P. C., Mijts, B. N., Petri, R., Watts, K. T., Schmidt-Dannert, C.
    Alteration of product specificity of Aeropyrum pernix farnesylgeranyl diphosphate synthase (Fgs) by directed evolution.
    Protein Eng. Des. Sel. 17 : 771-777 (2004). [PMID: 15548566]

[EC created 2010]