EC 2.5.1.76 - Cysteate synthase

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IntEnz Enzyme Nomenclature
EC 2.5.1.76

Names

Accepted name:
cysteate synthase
Systematic name:
sulfite:O-phospho-L-serine sulfotransferase (phosphate-hydrolysing, L-cysteate-forming)

Reaction

Cofactor

Comments:

A pyridoxal-phosphate protein. It is highly specific for O-phospho-L-serine and sulfite. The reaction proceeds through a dehydroalanine (2-aminoacrylic acid) intermediate. The enzyme from Methanosarcina acetivorans is evolutionarily related to threonine synthase (EC 4.2.3.1), but the reaction is more similar to that of O-phosphoserine sulfhydrylase (EC 2.5.1.65).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0044686
UniProtKB/Swiss-Prot: (12) [show] [UniProt]

References

  1. Graham, D. E., Taylor, S. M., Wolf, R. Z., Namboori, S. C.
    Convergent evolution of coenzyme M biosynthesis in the Methanosarcinales: cysteate synthase evolved from an ancestral threonine synthase.
    Biochem. J. 424: 467-478 (2009). [PMID: 19761441]

[EC 2.5.1.76 created 2009]