EC - 1,4-dihydroxy-2-naphthoate polyprenyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
1,4-dihydroxy-2-naphthoate polyprenyltransferase
Systematic name:
all-transall-trans-polyprenyl diphosphate:1,4-dihydroxy-2-naphthoate polyprenyltransferase



This enzyme catalyses a step in the synthesis of menaquinone, in which the prenyl chain synthesized by polyprenyl diphosphate synthase is transferred to 1,4-dihydroxy-2-naphthoate (DHNA). The bacterial enzyme is an inner membrane protein [1], with the C-terminus located in the periplasm [3]. It is highly specific for DHNA but not for a specific length of the prenyl chain [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Shineberg, B., Young, I. G.
    Biosynthesis of bacterial menaquinones: the membrane-associated 1,4-dihydroxy-2-naphthoate octaprenyltransferase of Escherichia coli.
    Biochemistry 15: 2754-2758 (1976). [PMID: 949474]
  2. Saito, Y., Ogura, K.
    Biosynthesis of menaquinones. Enzymatic prenylation of 1,4-dihydroxy-2-naphthoate by Micrococcus luteus membrane fractions.
    J. Biochem. 89: 1445-1452 (1981). [PMID: 7275947]
  3. Suvarna, K., Stevenson, D., Meganathan, R., Hudspeth, M. E.
    Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menA gene from Escherichia coli.
    J. Bacteriol. 180: 2782-2787 (1998). [PMID: 9573170]
  4. Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G.
    Global topology analysis of the Escherichia coli inner membrane proteome.
    Science 308: 1321-1323 (2005). [PMID: 15919996]

[EC created 2009]