EC 2.5.1.69 - Lavandulyl diphosphate synthase

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IntEnz Enzyme Nomenclature
EC 2.5.1.69

Names

Accepted name:
lavandulyl diphosphate synthase
Other name:
FDS-5
Systematic name:
dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming)

Reaction

Comments:

Lavandulyl diphosphate is a monoterpene with a non-head-to-tail linkage. It is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head-to-tail. When this enzyme is incubated with dimethylallyl diphosphate and isopentenyl diphosphate, it also forms the regular monoterpene geranyl diphosphate [2]. The enzyme from Artemisia tridentata (big sagebrush) forms both lavandulyl diphosphate and chrysanthemyl diphosphate (see EC 2.5.1.67, chrysanthemyl diphosphate synthase) when dimethylally diphosphate is the sole substrate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033851
UniProtKB/Swiss-Prot:

References

  1. Erickson, H.K. and Poulter, C.D.
    Chrysanthemyl diphosphate synthase. The relationship among chain elongation, branching, and cyclopropanation reactions in the isoprenoid biosynthetic pathway.
    J. Am. Chem. Soc. 125: 6886-6888 (2003). [PMID: 12783539]
  2. Hemmerlin, A., Rivera, S.B., Erickson, H.K. and Poulter, C.D.
    Enzymes encoded by the farnesyl diphosphate synthase gene family in the Big Sagebrush Artemisia tridentata ssp. spiciformis.
    J. Biol. Chem. 278: 32132-32140 (2003). [PMID: 12782626]

[EC 2.5.1.69 created 2007]