EC 2.5.1.68 - (2Z,6E)-farnesyl diphosphate synthase

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IntEnz Enzyme Nomenclature
EC 2.5.1.68

Names

Accepted name:
(2Z,6E)-farnesyl diphosphate synthase
Other names:
(Z)-farnesyl diphosphate synthase
Z-farnesyl diphosphate synthase
Systematic name:
geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase

Reaction

Cofactor

Comments:

Requires Mg2+ or Mn2+ for activity. The product of this reaction is an intermediate in the synthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, linker unit galactan and arabinan. Neryl diphosphate can also act as substrate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033850
UniProtKB/Swiss-Prot:

References

  1. Schulbach, M.C., Mahapatra, S., Macchia, M., Barontini, S., Papi, C., Minutolo, F., Bertini, S., Brennan, P.J. and Crick, D.C.
    Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis.
    J. Biol. Chem. 276: 11624-11630 (2001). [PMID: 11152452]

[EC 2.5.1.68 created 2007, modified 2010]