EC 18.104.22.168 - N2-(2-carboxyethyl)arginine synthase
IntEnz Enzyme Nomenclature
glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming)
10556 [IUBMB]D-glyceraldehyde 3-phosphateD-glyceraldehyde 3-phosphateName origin: UniProt - CHECKED (C)Formula: C3H5O6P
Charge: -2ChEBI compound status: CHECKED (C)L-arginineL-arginineName origin: UniProt - CHECKED (C)Formula: C6H15N4O2
Charge: 1ChEBI compound status: CHECKED (C)=H+H(+)Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)N2-(2-carboxyethyl)-L-arginineN(2)-(2-carboxyethyl)-L-arginineName origin: UniProt - CHECKED (C)Formula: C9H18N4O4
Charge: 0ChEBI compound status: CHECKED (C)
The enzyme requires thiamine diphosphate and catalyses the first step in the clavulanic-acid-biosynthesis pathway. The 2-hydroxy-3-oxo group transferred from glyceraldehyde 3-phosphate is isomerized during transfer to form the 2-carboxyethyl group.
Links to other databases
Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway.J. Biol. Chem. 279: 5685-5692 (2004). [PMID: 14623876]
Origin of the β-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction.J. Am. Chem. Soc. 121: 9223-9224 (1999).
[EC 22.214.171.124 created 2004]