EC - N2-(2-carboxyethyl)arginine synthase

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IntEnz Enzyme Nomenclature


Accepted name:
N2-(2-carboxyethyl)arginine synthase
Other names:
N2-(2-carboxyethyl)arginine synthetase
CEA synthetase
glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming)
Systematic name:
glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming)



The enzyme requires thiamine diphosphate and catalyses the first step in the clavulanic-acid-biosynthesis pathway. The 2-hydroxy-3-oxo group transferred from glyceraldehyde 3-phosphate is isomerized during transfer to form the 2-carboxyethyl group.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033848


  1. Caines, M.E., Elkins, J.M., Hewitson, K.S. and Schofield, C.J.
    Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway.
    J. Biol. Chem. 279: 5685-5692 (2004). [PMID: 14623876]
  2. Khaleeli, N., Li, R. and Townsend, C.A.
    Origin of the β-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction.
    J. Am. Chem. Soc. 121: 9223-9224 (1999).

[EC created 2004]