EC 2 - Transferases
EC 2.5 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1.65 - O-phosphoserine sulfhydrylase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.5.1.65
Names
Accepted name:
O-phosphoserine sulfhydrylase
Other
name:
O-phosphoserine(thiol)-lyase
Systematic name:
O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase
Reaction
- O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate
Cofactor
Comments:
A pyridoxal-phosphate protein. The enzyme from Aeropyrum pernix acts on both O-phospho-L-serine and O3-acetyl-L-serine, in contrast with EC 2.5.1.47, cysteine synthase, which acts only on O3-acetyl-L-serine.
Links to other databases
Gene Ontology:
GO:0033847
UniProtKB/Swiss-Prot:
References
-
A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1.FEBS Lett. 551 : 133-138 (2003). [PMID: 12965218]
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Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.J. Bacteriol. 185 : 2277-2284 (2003). [PMID: 12644499]
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Crystallization and preliminary X-ray diffraction analysis of O-acetylserine sulfhydrylase from Aeropyrum pernix K1.Acta Crystallogr. D Biol. Crystallogr. 59 : 338-340 (2003). [PMID: 12554945]
[EC 2.5.1.65 created 2004]