EC - Methionine adenosyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
methionine adenosyltransferase
Other names:
S-adenosyl-L-methionine synthetase
S-adenosylmethionine synthase
S-adenosylmethionine synthetase
ATP-methionine adenosyltransferase
AdoMet synthetase
adenosylmethionine synthetase
methionine S-adenosyltransferase
methionine-activating enzyme
Systematic name:
ATP:L-methionine S-adenosyltransferase


Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00369
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004478
CAS Registry Number: 9012-52-6
UniProtKB/Swiss-Prot: (789) [show] [UniProt]


  1. Cantoni, G.L.
    S-Adenosylmethionine: A new intermediate formed enzymatically from L-methionine and adenosinetriphosphate.
    J. Biol. Chem. 204 : 403-416 (1953).
  2. Cantoni, G.L. and Durell, J.
    Activation of methionine for transmethylation. II. The methionine-activating enzyme: studies on the mechanism of reaction.
    J. Biol. Chem. 225 : 1033-1048 (1957). [PMID: 13416303]
  3. Mudd, S.H. and Cantoni, G.L.
    Activation of methionine for transmethylation. III. The methionine-activating enzyme of bakers' yeast.
    J. Biol. Chem. 231 : 481-492 (1958). [PMID: 13538985]

[EC created 1961 as EC, transferred 1965 to EC]