EC 2 - Transferases
EC 2.5 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1.56 - N-acetylneuraminate synthase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.5.1.56
Names
Accepted name:
N-acetylneuraminate synthase
Other
names:
(NANA)condensing enzyme
N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating)
NeuAc synthase
N-acetylneuraminic acid synthase
N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating)
NeuAc synthase
N-acetylneuraminic acid synthase
Systematic name:
phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
Reaction
- phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0050462
CAS Registry Number:
37290-66-7
UniProtKB/Swiss-Prot:
References
-
Biosynthesis of sialic acids by Neisseria meningitidis.J. Biol. Chem. 237 : 3520-3526 (1962).
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Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1-M12.Biosci. Biotechnol. Biochem. 61 : 2046-2050 (1997). [PMID: 9438985]
[EC 2.5.1.56 created 1972 as EC 4.1.3.19, transferred 2002 to EC 2.5.1.56]