EC - N-acetylneuraminate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
N-acetylneuraminate synthase
Other names:
(NANA)condensing enzyme
N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating)
NeuAc synthase
N-acetylneuraminic acid synthase
Systematic name:
phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)


Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050462
CAS Registry Number: 37290-66-7


  1. Blacklow, R.S. and Warren, L.
    Biosynthesis of sialic acids by Neisseria meningitidis.
    J. Biol. Chem. 237 : 3520-3526 (1962).
  2. Komaki, E., Ohta, Y. and Tsukada, Y.
    Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1-M12.
    Biosci. Biotechnol. Biochem. 61 : 2046-2050 (1997). [PMID: 9438985]

[EC created 1972 as EC, transferred 2002 to EC]