EC 2 - Transferases
EC 2.5 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1.56 - N-acetylneuraminate synthase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.5.1.56
Names
Accepted name:
N-acetylneuraminate synthase
Other
names:
(NANA)condensing enzyme
N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating)
NeuAc synthase
N-acetylneuraminic acid synthase
N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating)
NeuAc synthase
N-acetylneuraminic acid synthase
Systematic name:
phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
Reaction
-
19273 [IUBMB]+H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)+N-acetyl-D-mannosamineName origin: UniProt - CHECKED (C)Formula: C8H15NO6
Charge: 0ChEBI compound status: CHECKED (C)phosphoenolpyruvateName origin: UniProt - CHECKED (C)Formula: C3H2O6P
Charge: -3ChEBI compound status: CHECKED (C)=+N-acetylneuraminateName origin: UniProt - CHECKED (C)Formula: C11H18NO9
Charge: -1ChEBI compound status: CHECKED (C)
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0050462
CAS Registry Number:
37290-66-7
UniProtKB/Swiss-Prot:
References
-
Biosynthesis of sialic acids by Neisseria meningitidis.J. Biol. Chem. 237: 3520-3526 (1962).
-
Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1-M12.Biosci. Biotechnol. Biochem. 61: 2046-2050 (1997). [PMID: 9438985]
[EC 2.5.1.56 created 1972 as EC 4.1.3.19, transferred 2002 to EC 2.5.1.56]