EC 2 - Transferases
EC 2.5 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1.31 - ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.5.1.31
Names
Accepted name:
ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
Other
names:
ditrans,polycis-undecaprenyl-diphosphate synthase
UPP synthetase
bactoprenyl-diphosphate synthase
undecaprenyl diphosphate synthetase
undecaprenyl pyrophosphate synthetase
undecaprenyl-diphosphate synthase
undecaprenyl pyrophosphate synthase
ditrans,polycis-undecaprenylcistransferase
UPP synthetase
bactoprenyl-diphosphate synthase
undecaprenyl diphosphate synthetase
undecaprenyl pyrophosphate synthetase
undecaprenyl-diphosphate synthase
undecaprenyl pyrophosphate synthase
ditrans,polycis-undecaprenylcistransferase
Systematic name:
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 8 isopentenyl units)
Reaction
- (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate
Comments:
Undecaprenyl pyrophosphate synthase catalyses the consecutive condensation reactions of a farnesyl diphosphate with eight isopentenyl diphosphates, in which new cis-double bonds are formed, to generate undecaprenyl diphosphate that serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall [3].
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC00817
Gene Ontology:
GO:0008834
CAS Registry Number:
52350-87-5
References
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Undecaprenyl pyrophosphate synthetase from Lactobacillus plantarum: a dimeric protein.Arch. Biochem. Biophys. 230 : 49-60 (1984). [PMID: 6712246]
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Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase.J. Biochem. 92 : 1527-1537 (1982). [PMID: 6818223]
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Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis.J. Biol. Chem. 280 : 20762-20774 (2005). [PMID: 15788389]
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Mechanism of product chain length determination and the role of a flexible loop in Escherichia coli undecaprenyl-pyrophosphate synthase catalysis.J. Biol. Chem. 276 : 47474-47482 (2001). [PMID: 11581264]
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Mutational analysis of allylic substrate binding site of Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase.Biochemistry 42 : 4035-4041 (2003). [PMID: 12680756]
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Crystal structure of cis-prenyl chain elongating enzyme, undecaprenyl diphosphate synthase.Proc. Natl. Acad. Sci. USA 98 : 4337-4342 (2001). [PMID: 11287651]
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Product distribution and pre-steady-state kinetic analysis of Escherichia coli undecaprenyl pyrophosphate synthase reaction.Biochemistry 39 : 10936-10942 (2000). [PMID: 10978182]
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Significance of highly conserved aromatic residues in Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase.J. Biochem. 134 : 819-826 (2003). [PMID: 14769870]
[EC 2.5.1.31 created 1984, modified 2010, modified 2011]