EC - Heptaprenyl diphosphate synthase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
heptaprenyl diphosphate synthase
Other names:
all-trans-heptaprenyl-diphosphate synthase
heptaprenyl pyrophosphate synthase
heptaprenyl pyrophosphate synthetase
HepPP synthase
heptaprenylpyrophosphate synthetase
Systematic name:
all-trans-hexaprenyl-diphosphate:isopentenyl-diphosphate hexaprenyltranstransferase



This enzyme catalyses the condensation reactions resulting in the formation of all-trans-heptaprenyl diphosphate, the isoprenoid side chain of ubiquinone-7 and menaquinone-7. The enzyme adds four isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0036422
CAS Registry Number: 74506-59-5


  1. Takahashi, I., Ogura, K. and Seto, S.
    Heptaprenyl pyrophosphate synthetase from Bacillus subtilis.
    J. Biol. Chem. 255: 4539-4543 (1980). [PMID: 6768722]
  2. Zhang, Y. W., Koyama, T., Marecak, D. M., Prestwich, G. D., Maki, Y., Ogura, K.
    Two subunits of heptaprenyl diphosphate synthase of Bacillus subtilis form a catalytically active complex.
    Biochemistry 37: 13411-13420 (1998). [PMID: 9748348]
  3. Zhang, Y. W., Li, X. Y., Sugawara, H., Koyama, T.
    Site-directed mutagenesis of the conserved residues in component I of Bacillus subtilis heptaprenyl diphosphate synthase.
    Biochemistry 38: 14638-14643 (1999). [PMID: 10545188]
  4. Suzuki, T., Zhang, Y. W., Koyama, T., Sasaki, D. Y., Kurihara, K.
    Direct observation of substrate-enzyme complexation by surface forces measurement.
    J. Am. Chem. Soc. 128: 15209-15214 (2006). [PMID: 17117872]

[EC created 1984, modified 2010]