EC - Spermine synthase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
spermine synthase
Other names:
spermidine aminopropyltransferase
spermine synthetase
S-adenosylmethioninamine:spermidine 3-aminopropyltransferase
Systematic name:
S-adenosyl 3-(methylsulfanyl)propylamine:spermidine 3-aminopropyltransferase



The enzyme from mammalia is highly specific for spermidine [2,3]. cf. EC (spermidine synthase) and EC (sym-norspermidine synthase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC01033
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016768
CAS Registry Number: 74812-43-4


  1. Hibasami, H., Borchardt, R.T., Chen, S.-Y., Coward, J.K. and Pegg, A.E.
    Studies of inhibition of rat spermidine synthase and spermine synthase.
    Biochem. J. 187: 419-428 (1980). [PMID: 7396856]
  2. Pajula, R.-L., Raina, A. and Eloranta, T.
    Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain.
    Eur. J. Biochem. 101: 619-626 (1979). [PMID: 520313]
  3. Pegg, A. E., Shuttleworth, K., Hibasami, H.
    Specificity of mammalian spermidine synthase and spermine synthase.
    Biochem. J. 197: 315-320 (1981). [PMID: 6798961]

[EC created 1982, modified 2013]