EC 2.5.1.18
- Glutathione transferase
IntEnz Enzyme Nomenclature
EC 2.5.1.18
Names
Accepted name:
glutathione transferase
Other
names:
S-(hydroxyalkyl)glutathione lyase
glutathione S-alkyl transferase
glutathione S-alkyltransferase
glutathione S-aralkyltransferase
glutathione S-aryltransferase
glutathione S-transferase
Systematic name:
RX:glutathione R-transferase
Reaction
-
RX + glutathione = HX + R-S-glutathione
Comments:
A group of enzymes of broad specificity. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. Also catalyses the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange.
Links to other databases
CAS Registry Number:
50812-37-8
ACLG_ASPOR
ATIMG_ASPTN
DHAR1-2_ARATH
DHAR1_ARATH
DHAR1_ORYSJ
DHAR2_ARATH
DHAR2_ORYSJ
DHAR3_ARATH
DHAR4_ARATH
FOSA_PSEAE
FOSA_SERMA
GLIG_ASPFU
GLRX1_YEAST
GLRX2-2_YEAST
GLRX2_YEAST
GST-2_ANOGA
GST1A_ANOGA
GST1B_ANOGA
GST1C_ANOGA
GST1D_ANOGA
GST1_ASCSU
GST1_BLAGE
GST1_ONCVO
GST1_SCHPO
GST1_YEAST
GST23_MAIZE
GST26_FASHE
GST26_SCHJA
GST26_SCHMA
GST27_FASHE
GST27_SCHMA
GST28_FASHE
GST28_SCHBO
GST28_SCHHA
GST28_SCHJA
GST28_SCHMA
GST29_FASHE
GST2_ASCSU
GST2_CAEEL
GST2_HUMAN
GST2_MANSE
GST2_SCHPO
GST2_YEAST
GST36_CAEEL
GST3_CAEEL
GST3_SCHPO
GST4_CAEEL
GST5_CAEEL
GST5_CHICK
GST67_DICLA
GST6_CAEEL
GST7_CAEEL
GST82_DICLA
GST8_CAEEL
GST9_CAEEL
GSTA1_ANTST
GSTA1_BOVIN
GSTA1_CAVPO
GSTA1_CHICK
GSTA1_DICDI
GSTA1_HUMAN
GSTA1_MOUSE
GSTA1_PIG
GSTA1_RABIT
GSTA1_RAT
GSTA2_BOVIN
GSTA2_CHICK
GSTA2_DICDI
GSTA2_HUMAN
GSTA2_MOUSE
GSTA2_RAT
GSTA3_CHICK
GSTA3_DICDI
GSTA3_HUMAN
GSTA3_MOUSE
GSTA3_RAT
GSTA4-2_HUMAN
GSTA4_BOVIN
GSTA4_DICDI
GSTA4_HUMAN
GSTA4_MOUSE
GSTA4_RAT
GSTA5_DICDI
GSTA5_HUMAN
GSTA5_RAT
GSTA6_RAT
GSTA_ECO57
GSTA_ECOLI
GSTA_PLEPL
GSTA_RABIT
GSTB_ECOL6
GSTB_ECOLI
GSTB_SHIFL
GSTD1_DROME
GSTD2_DROME
GSTD4_DROME
GSTD5_DROME
GSTD6_DROME
GSTD7_DROME
GSTE1_PSEUO
GSTE2_PSEUO
GSTEE_DROME
GSTE_PSEFL
GSTE_PSEP1
GSTE_PSEPU
GSTE_PSEUF
GSTF1_ARATH
GSTF1_MAIZE
GSTF1_ORYSJ
GSTF1_POPEU
GSTF1_TOBAC
GSTF1_WHEAT
GSTF2_ARATH
GSTF2_ORYSJ
GSTF2_POPEU
GSTF2_TOBAC
GSTF2_WHEAT
GSTF3_ARATH
GSTF3_MAIZE
GSTF4-2_ARATH
GSTF4_ARATH
GSTF4_MAIZE
GSTF5_ARATH
GSTF6_ARATH
GSTF7_ARATH
GSTF8-2_ARATH
GSTF8_ARATH
GSTF9-2_ARATH
GSTF9_ARATH
GSTFA_ARATH
GSTFB_ARATH
GSTFC_ARATH
GSTFD_ARATH
GSTFE_ARATH
GSTF_BRAOT
GSTF_HYOMU
GSTF_SILVU
GSTK1-2_HUMAN
GSTK1-3_HUMAN
GSTK1-4_HUMAN
GSTK1_CAEEL
GSTK1_HUMAN
GSTK1_MOUSE
GSTK1_RAT
GSTK2_CAEEL
GSTL1-2_ARATH
GSTL1_ARATH
GSTL2_ARATH
GSTL3_ARATH
GSTM1-2_HUMAN
GSTM1_BOVIN
GSTM1_CAVPO
GSTM1_DERPT
GSTM1_HUMAN
GSTM1_MACFA
GSTM1_MOUSE
GSTM1_RAT
GSTM2-2_HUMAN
GSTM2_CHICK
GSTM2_HUMAN
GSTM2_MACFA
GSTM2_MACFU
GSTM2_MOUSE
GSTM2_PONAB
GSTM2_RAT
GSTM3_HUMAN
GSTM3_MACFU
GSTM3_MOUSE
GSTM4-2_HUMAN
GSTM4-3_HUMAN
GSTM4_HUMAN
GSTM4_MOUSE
GSTM4_RAT
GSTM5_HUMAN
GSTM5_MESAU
GSTM5_MOUSE
GSTM5_RAT
GSTM6_MOUSE
GSTM7_MOUSE
GSTM7_RAT
GSTMU_CRILO
GSTMU_MESAU
GSTMU_RABIT
GSTM_TYRPU
GSTO1-2_HUMAN
GSTO1-3_HUMAN
GSTO1_CAEEL
GSTO1_HUMAN
GSTO1_MOUSE
GSTO1_PIG
GSTO1_RAT
GSTO2-2_HUMAN
GSTO2-3_HUMAN
GSTO2_CAEBR
GSTO2_CAEEL
GSTO2_HUMAN
GSTO2_MOUSE
GSTO2_RAT
GSTO_APLCA
GSTP1_BOVIN
GSTP1_BUFBU
GSTP1_CAEEL
GSTP1_CAPHI
GSTP1_CRILO
GSTP1_CRIMI
GSTP1_HUMAN
GSTP1_MACMU
GSTP1_MESAU
GSTP1_MOUSE
GSTP1_PIG
GSTP1_PONAB
GSTP1_RAT
GSTP1_XENLA
GSTP2_BUFBU
GSTP2_MOUSE
GSTPA_CAEEL
GSTP_DIRIM
GSTP_ONCVO
GSTS1_DROME
GSTT1-2_HUMAN
GSTT1_ARATH
GSTT1_BOVIN
GSTT1_CHICK
GSTT1_DROER
GSTT1_DROMA
GSTT1_DROSE
GSTT1_DROSI
GSTT1_DROTE
GSTT1_DROYA
GSTT1_HUMAN
GSTT1_LUCCU
GSTT1_MANSE
GSTT1_MOUSE
GSTT1_MUSDO
GSTT1_RAT
GSTT2_ANOGA
GSTT2_ARATH
GSTT2_HUMAN
GSTT2_MOUSE
GSTT2_MUSDO
GSTT2_RAT
GSTT3_ARATH
GSTT3_MOUSE
GSTT3_MUSDO
GSTT4_HUMAN
GSTT4_MOUSE
GSTT4_MUSDO
GSTT4_RAT
GSTT7_ANOGA
GSTU1_ARATH
GSTU1_ORYSI
GSTU1_ORYSJ
GSTU2_ARATH
GSTU3_ARATH
GSTU4_ARATH
GSTU5_ARATH
GSTU6_ARATH
GSTU6_ORYSJ
GSTU7_ARATH
GSTU8_ARATH
GSTU9-2_ARATH
GSTU9_ARATH
GSTUA_ARATH
GSTUB_ARATH
GSTUC_ARATH
GSTUD_ARATH
GSTUE_ARATH
GSTUF_ARATH
GSTUG_ARATH
GSTUH_ARATH
GSTUI_ARATH
GSTUJ_ARATH
GSTUK_ARATH
GSTUL_ARATH
GSTUM_ARATH
GSTUN_ARATH
GSTUO_ARATH
GSTUP_ARATH
GSTUQ_ARATH
GSTUR_ARATH
GSTUS_ARATH
GSTX1_NICPL
GSTX1_SOLTU
GSTX1_TOBAC
GSTX2_MAIZE
GSTX2_TOBAC
GSTX3_SOYBN
GSTX3_TOBAC
GSTX4_TOBAC
GSTX6_SOYBN
GSTXA_TOBAC
GSTXC_TOBAC
GSTY2_PICKU
GSTZ1-2_ARATH
GSTZ1_ARATH
GSTZ1_DIACA
GSTZ2_ARATH
GSTZ2_DIACA
GSTZ_EUPES
GSTZ_WHEAT
GST_ALTAL
GST_ANOGA
GST_ASADI
GST_BRUAN
GST_COCIM
GST_HAEIN
GST_LACPN
GST_MUSDO
GST_NOTSL
GST_PLAF7
GST_PLAFA
GST_PLAVI
GST_PLAYO
GST_PROMI
GST_SERMA
GST_XANCP
GTO1_YEAST
GTO2_SCHPO
GTO2_YEAST
GTO3_YEAST
HPGDS_CHICK
HPGDS_HUMAN
HPGDS_MOUSE
HPGDS_RAT
HPM2_HYPSB
LANC1_BOVIN
LANC1_DANRE
LANC1_HUMAN
LANC1_MOUSE
LANC1_RAT
MAAI-2_HUMAN
MAAI-3_HUMAN
MAAI1_DROME
MAAI2-2_DROME
MAAI2-3_DROME
MAAI2_DROME
MAAI_HUMAN
MAAI_MOUSE
MAAI_RAT
MGST1-2_HUMAN
MGST1_BOVIN
MGST1_HUMAN
MGST1_MOUSE
MGST1_PIG
MGST1_RAT
MGST2-2_HUMAN
MGST2_BOVIN
MGST2_HUMAN
MGST2_MOUSE
MGST_DICDI
PTGES_BOVIN
PTGES_CANLF
PTGES_HORSE
PTGES_HUMAN
PTGES_MACFA
PTGES_MOUSE
PTGES_RAT
SIRG_LEPMC
TCHQD_ARATH
TCPG_CLAP2
VERG_CLORO
YC12_SCHPO
YFCF_ECOLI
YP52_SCHPO
References
-
Habig, W.H., Pabst, M.J. and Jakoby, W.B.
Glutathione S-transferases. The first enzymatic step in mercapturic acid formation
. J. Biol. Chem.
249
:
7130-7139
(1974).
[PMID:
4436300]
-
Jakoby, W.B.
The glutathione S-transferases: a group of multifunctional detoxification proteins.
Adv. Enzymol. Relat. Areas Mol. Biol.
46
:
383-383
(1978).
[PMID:
345769]
-
Jakoby, W.B.
Glutathione transferases: an overview.
Methods Enzymol.
113
:
495-499
(1985).
-
Keen, J.H. and Jakoby, W.B.
Glutathione transferases. Catalysis of nucleophilic reactions of glutathione.
J. Biol. Chem.
253
:
5654-5657
(1978).
[PMID:
670218]
-
Sheehan, D., Meade, G., Foley, V.M. and Dowd, C.A.
Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily.
Biochem. J.
360
:
1-16
(2001).
[PMID:
11695986]
[EC 2.5.1.18 created 1976 (EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7 created 1972, incorporated 1976)]