EC - Spermidine synthase

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IntEnz Enzyme Nomenclature


Accepted name:
spermidine synthase
Other names:
putrescine aminopropyltransferase
spermidine synthetase
Systematic name:
S-adenosyl 3-(methylsulfanyl)propylamine:putrescine 3-aminopropyltransferase



The enzymes from the plant Glycine max and from mammalia are highly specific for putrescine as the amine acceptor [2,7]. The enzymes from the bacteria Escherichia coli and Thermotoga maritima prefer putrescine but are more tolerant towards other amine acceptors, such as spermidine and cadaverine [5,6]. cf. EC (spermine synthase) and EC (sym-norspermidine synthase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC01033
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004766
CAS Registry Number: 37277-82-0
UniProtKB/Swiss-Prot: (228) [show] [UniProt]


  1. Hannonen, P., Janne, J. and Raina, A.
    Partial purification and characterization of spermine synthase from rat brain.
    Biochim. Biophys. Acta 289 : 225-231 (1972). [PMID: 4564056]
  2. Pegg, A.E., Shuttleworth, K. and Hibasami, H.
    Specificity of mammalian spermidine synthase and spermine synthase.
    Biochem. J. 197 : 315-320 (1981). [PMID: 6798961]
  3. Tabor, C.W.
    Propylamine transferase (spermidine synthesis).
    Methods Enzymol. 5 : 761-765 (1962).
  4. Tabor, H. and Tabor, C.W.
    Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines.
    Adv. Enzymol. Relat. Areas Mol. Biol. 36 : 203-268 (1972). [PMID: 4628436]

[EC created 1972, modified 1982, modified 2013]