EC 2 - Transferases
EC 2.5 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1.16 - Spermidine synthase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.5.1.16
Names
Accepted name:
spermidine synthase
Other
names:
aminopropyltransferase
putrescine aminopropyltransferase
spermidine synthetase
SpeE
putrescine aminopropyltransferase
spermidine synthetase
SpeE
Systematic name:
S-adenosyl 3-(methylsulfanyl)propylamine:putrescine 3-aminopropyltransferase
Reaction
- S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine
Comments:
The enzymes from the plant Glycine max and from mammalia are highly specific for putrescine as the amine acceptor [2,7]. The enzymes from the bacteria Escherichia coli and Thermotoga maritima prefer putrescine but are more tolerant towards other amine acceptors, such as spermidine and cadaverine [5,6]. cf. EC 2.5.1.22 (spermine synthase) and EC 2.5.1.23 (sym-norspermidine synthase).
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC01033
Gene Ontology:
GO:0004766
CAS Registry Number:
37277-82-0
References
-
Partial purification and characterization of spermine synthase from rat brain.Biochim. Biophys. Acta 289 : 225-231 (1972). [PMID: 4564056]
-
Specificity of mammalian spermidine synthase and spermine synthase.Biochem. J. 197 : 315-320 (1981). [PMID: 6798961]
-
Propylamine transferase (spermidine synthesis).Methods Enzymol. 5 : 761-765 (1962).
-
Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines.Adv. Enzymol. Relat. Areas Mol. Biol. 36 : 203-268 (1972). [PMID: 4628436]
[EC 2.5.1.16 created 1972, modified 1982, modified 2013]