EC 2.5.1.153 - Adenosine tuberculosinyltransferase

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IntEnz Enzyme Nomenclature
EC 2.5.1.153

Names

Accepted name:
adenosine tuberculosinyltransferase
Other name:
Rv3378c
Systematic name:
tuberculosinyl diphosphate:adenosine tuberculosinyltransferase

Reactions

Comments:

The enzyme, characterized from the bacterial pathogen Mycobacterium tuberculosis, produces 1-tuberculosinyladenosine, an unusual terpene nucleoside that acts as a phagolysosome disruptor by neutralizing the pH, resulting in swelling of the lysosome and obliteration of its multilamellar structure. Formerly 3.1.7.8 and EC 3.1.7.9.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Layre, E., Lee, H. J., Young, D. C., Martinot, A. J., Buter, J., Minnaard, A. J., Annand, J. W., Fortune, S. M., Snider, B. B., Matsunaga, I., Rubin, E. J., Alber, T., Moody, D. B.
    Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c.
    Proc Natl Acad Sci U S A 111 : 2978-2983 (2014). [PMID: 24516143]
  2. Hoshino, T., Nakano, C., Ootsuka, T., Shinohara, Y., Hara, T.
    Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis.
    Org. Biomol. Chem. 9 : 2156-2165 (2011). [PMID: 25910243]
  3. Buter, J., Cheng, T. Y., Ghanem, M., Grootemaat, A. E., Raman, S., Feng, X., Plantijn, A. R., Ennis, T., Wang, J., Cotton, R. N., Layre, E., Ramnarine, A. K., Mayfield, J. A., Young, D. C., Jezek Martinot, A., Siddiqi, N., Wakabayashi, S., Botella, H., Calderon, R., Murray, M., Ehrt, S., Snider, B. B., Reed, M. B., Oldfield, E., Tan, S., Rubin, E. J., Behr, M. A., van der Wel, N. N., Minnaard, A. J., Moody, D. B.
    Mycobacterium tuberculosis releases an antacid that remodels phagosomes.
    Nat Chem Biol 15 : 889-899 (2019). [PMID: 31427817]

[EC 2.5.1.153 created 2011 as EC 3.1.7.8 and EC 3.1.7.9, transferred 2020 to EC 2.5.1.153]