EC - Dihydropteroate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
dihydropteroate synthase
Other names:
7,8-dihydropteroate synthase
7,8-dihydropteroate synthetase
7,8-dihydropteroic acid synthetase
dihydropteroate pyrophosphorylase
dihydropteroate synthetase
dihydropteroic synthetase
dihydropteroate diphosphorylase
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase
Systematic name:
6-hydroxymethyl-7,8-dihydropterin-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase



The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the plant Arabidopsis thaliana also harbors the activity of EC, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [4], while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with the two above mentioned activities as well as EC, dihydroneopterin aldolase [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00630 , PROSITE:PDOC50972
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004156
CAS Registry Number: 9055-61-2
UniProtKB/Swiss-Prot: (53) [show] [UniProt]


  1. Richey, D.P. and Brown, G.M.
    The biosynthesis of folic acid. IX. Purification and properties of the enzymes required for the formation of dihydropteroic acid.
    J. Biol. Chem. 244 : 1582-1592 (1969). [PMID: 4304228]
  2. Shiota, T., Baugh, C.M., Jackson, R. and Dillard, R.
    The enzymatic synthesis of hydroxymethyldihydropteridine pyrophosphate and dihydrofolate.
    Biochemistry 8 : 5022-5028 (1969). [PMID: 4312465]
  3. Guldener, U., Koehler, G. J., Haussmann, C., Bacher, A., Kricke, J., Becher, D., Hegemann, J. H.
    Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growth.
    Mol. Biol. Cell 15 : 3811-3828 (2004). [PMID: 15169867]
  4. Storozhenko, S., Navarrete, O., Ravanel, S., De Brouwer, V., Chaerle, P., Zhang, G. F., Bastien, O., Lambert, W., Rebeille, F., Van Der Straeten, D.
    Cytosolic hydroxymethyldihydropterin pyrophosphokinase/dihydropteroate synthase from Arabidopsis thaliana: a specific role in early development and stress response.
    J. Biol. Chem. 282 : 10749-10761 (2007). [PMID: 17289662]

[EC created 1972, modified 2015]